文章摘要
吴 飏,张 纯,陆子鹏,蒋奎荣,张晓艳.ERCC1基因多态性与胰腺导管腺癌易感性的Meta分析[J].南京医科大学学报,2019,(6):941~945
ERCC1基因多态性与胰腺导管腺癌易感性的Meta分析
Association between ERCC1 gene polymorphisms and risk of pancreatic cancer:a Meta⁃analysis
投稿时间:2018-12-05  
DOI:10.7655/NYDXBNS20190630
中文关键词: 切除修复交叉互补基因1  基因多态性  胰腺导管腺癌  Meta分析
英文关键词: ERCC1  polymorphisms  pancreatic ductal adenocarcinoma  Meta⁃analysis
基金项目:国家自然科学基金面上项目(81871980);江苏省科技厅临床前沿技术(BE2016788);医学重点人才(ZDRCB2016004);国家重点研究计划?973计划(2016J6)
作者单位
吴 飏 慕尼黑大学附属医院外科德国 慕尼黑 81377 
张 纯 慕尼黑大学附属医院外科德国 慕尼黑 81377 
陆子鹏 南京医科大学第一附属医院胰腺中心江苏 南京 210029 
蒋奎荣 南京医科大学第一附属医院胰腺中心江苏 南京 210029 
张晓艳 南京医科大学第一附属医院血液科江苏 南京 210029 
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中文摘要:
      目的:探讨切除修复交叉互补基因1(excision repair cross complementing 1,ERCC1)2种最常见的基因多态性(rs3212986、rs11615)与胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)患病风险的相关性。方法:检索PubMed、EMBASE、Web of Science、中国知网文献数据库,查找国内外关于ERCC1多态性(rs3212986、rs11615)与PDAC易感性关系的病例对照研究。由2名评价者根据纳入标准分别独立筛选文献并提取数据后,采用Stata12.0软件进行Meta分析。结果:共纳入8项病例对照研究,其中ERCC1 rs3212986纳入4项研究共1 934例患者,rs11615纳入4项研究共2 547例患者。结果显示,ERCC1 rs3212986可显著提高人群PDAC的患病风险(CA vs. AA:OR=1.34,95% CI:1.11~1.63;CC vs. AA:OR=2.33,95% CI:1.73~3.14;AC+CC vs. AA:OR=1.50,95% CI:1.25~1.80;CC vs. CA+AA:OR=1.98,95% CI:1.50~2.62;C vs. A:OR=1.45,95% CI:1.27~1.66);而ERCC1 rs11615则与PDAC患病风险无关(CT vs. TT:OR=1.02,95% CI:0.87~1.21;CC vs. TT:OR=1.21;95% CI:0.93~1.56;TC+CC vs. TT:OR=1.06,95% CI:0.91~1.24;CC vs. CT+TT:OR=1.20,95% CI:0.94~1.53;C vs. T:OR=1.08,95% CI:0.96~1.21)。结论:ERCC1 rs3212986可明显增加PDAC发病风险,rs11615则与PDAC易感性无关。
英文摘要:
      Objective:This study aims to assess the association between excision repair cross complementing 1(ERCC1)gene polymorphisms(rs3212986、rs11615)and susceptibility to pancreatic ductal adenocarcinoma. Methods:Evidence for this association was obtained by searching PubMed,Web of Science,EMBASE and CNKI. Data were extracted using standardized forms and odds ratios(ORs)with 95% confidence intervals(CIs)were used to assess the strength of association. All statistical analyses were performed using Stata 12.0. Results:Eight studies were enrolled in our final combined analysis. The results showed evidence for significant association between rs3212986 polymorphism and PDAC risk(CA vs. AA:OR=1.34,95% CI:1.11?1.63;CC vs. AA:OR=2.33,95% CI:1.73?3.14;AC+CC vs. AA:OR=1.50,95% CI:1.25?1.80;CC vs. CA+AA:OR=1.98,95% CI:1.50?2.62;C vs. A:OR=1.45,95% CI:1.27?1.66). However,no association was observed between rs11615 and PDAC risk(CT vs. TT:OR=1.02,95% CI:0.87?1.21;CC vs. TT:OR=1.21;95% CI:0.93?1.56;TC+CC vs. TT:OR=1.06,95% CI:0.91?1.24;CC vs. CT+TT:OR=1.20,95% CI:0.94?1.53;C vs. T:OR=1.08,95% CI:0.96?1.21). Conclusion:The allele gene C of ERCC rs3212986 is significantly associated with the risk of PDAC,while rs11615 might not contribute to the risk of PDAC.
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