白细胞介素33在妊娠相关疾病中的研究进展
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省妇幼健康科研项目(F201542)


Research progress of interleukin⁃33 in pregnancy⁃related diseases
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    白细胞介素(interleukin,IL)-33在多种组织和细胞均可表达,其在稳态维持和环境应激应答中起重要作用,能通过IL-33/ST2信号通路参与众多疾病的发生与发展。研究表明IL-33参与母胎界面免疫耐受和促进胎盘形成等正常妊娠过程,而IL-33表达异常与流产、早产、子痫前期等妊娠相关疾病的发生发展有关,深入研究IL-33在妊娠中的作用,可能为正常妊娠维持及妊娠特发疾病的诊治提供新思路。

    Abstract:

    Interleukin(interleukin,IL)-33 can be expressed in various tissues and cells. It plays an important role in the maintenance of homeostasis and the response to environmental stress. It can participate in the formation and development of many diseases through IL-33/ST2 signaling pathway. Studies have shown that IL-33 is involved in maternal and fetal interface immune tolerance and placenta formation,while abnormal expression of IL-33 is related to the formation and development of pregnancy-related diseases such as abortion,preterm delivery and preeclampsia. The roles of IL-33 in pregnancy are deeply studied,and it may provide new ideas for the diagnosis and treatment of normal pregnancy maintenance and pregnancy specific diseases.

    参考文献
    相似文献
    引证文献
引用本文

陆凯丽,张国英.白细胞介素33在妊娠相关疾病中的研究进展[J].南京医科大学学报(自然科学版),2019,(7):1076-1081

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2018-11-25
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2019-08-01
  • 出版日期: