文章摘要
陆凯丽,张国英.白细胞介素33在妊娠相关疾病中的研究进展[J].南京医科大学学报,2019,(7):1076~1081
白细胞介素33在妊娠相关疾病中的研究进展
Research progress of interleukin⁃33 in pregnancy⁃related diseases
投稿时间:2018-11-25  
DOI:10.7655/NYDXBNS20190729
中文关键词: 白细胞介素33  信号通路  免疫  妊娠
英文关键词: interleukin⁃33  signaling pathway  immunity  pregnancy
基金项目:江苏省妇幼健康科研项目(F201542)
作者单位
陆凯丽 南京医科大学第一附属医院产科江苏 南京 210029 
张国英 南京医科大学第一附属医院产科江苏 南京 210029 
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中文摘要:
      白细胞介素(interleukin,IL)?33在多种组织和细胞均可表达,其在稳态维持和环境应激应答中起重要作用,能通过IL?33/ST2信号通路参与众多疾病的发生与发展。研究表明IL?33参与母胎界面免疫耐受和促进胎盘形成等正常妊娠过程,而IL?33表达异常与流产、早产、子痫前期等妊娠相关疾病的发生发展有关,深入研究IL?33在妊娠中的作用,可能为正常妊娠维持及妊娠特发疾病的诊治提供新思路。
英文摘要:
      Interleukin(interleukin,IL)?33 can be expressed in various tissues and cells. It plays an important role in the maintenance of homeostasis and the response to environmental stress. It can participate in the formation and development of many diseases through IL?33/ST2 signaling pathway. Studies have shown that IL?33 is involved in maternal and fetal interface immune tolerance and placenta formation,while abnormal expression of IL?33 is related to the formation and development of pregnancy?related diseases such as abortion,preterm delivery and preeclampsia. The roles of IL?33 in pregnancy are deeply studied,and it may provide new ideas for the diagnosis and treatment of normal pregnancy maintenance and pregnancy specific diseases.
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