文章摘要
陈 炜,于 亮.长链非编码RNA MALAT1在恶性肿瘤中的作用及机制研究进展[J].南京医科大学学报,2019,(7):1082~1087
长链非编码RNA MALAT1在恶性肿瘤中的作用及机制研究进展
Progress on the studies of functions and mechanisms of long non⁃coding RNA MALAT1 in tumors
投稿时间:2017-06-05  
DOI:10.7655/NYDXBNS20190730
中文关键词: MALAT1  非编码RNA  恶性肿瘤
英文关键词: MALAT1  non⁃coding RNA  tumor
基金项目:南京医科大学科技发展基金重点项目(2016NJMUZD083)
作者单位
陈 炜 南京医科大学附属淮安第一医院呼吸内科江苏 淮安 223300 
于 亮 南京医科大学附属淮安第一医院血液科江苏 淮安 223300 
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中文摘要:
      长链非编码RNA(long noncoding RNA,lncRNA)近几年成为研究热点,已证实某些lncRNA的异常表达与肿瘤的发生、发展关系密切。其中,肺腺癌转移相关转录本1(metastasis associated lung adenocarcinoma transcript 1,MALAT1)在转移性肿瘤细胞中表达上调。MALAT1广泛表达于正常组织,而在多种人类肿瘤组织、细胞及外周血中的表达均存在显著差异性,提示其可能在肿瘤的发生发展及侵袭转移等过程中起重要作用。文章就MALAT1的分子特点、功能以及在肿瘤分子病理学中的研究进展作一综述。
英文摘要:
      Long non?coding RNA(lncRNA)has become a research hotspot in recent years,and it has been proved that abnormal expressions of some certain lncRNAs are closely related to the occurrence and progression of tumors. Among many kinds of lncRNAs,the metastasis associated lung adenocarcinoma transcript 1(MALAT1)is upregulated in metastatic carcinoma cells. MALAT1 was widely expressed in normal tissues,and the expressions displayed significant differences in a variety of human tumor tissues,cells and peripheral blood,which suggests that MALAT1 may play an important role in the process of tumorigenesis,progression,invasion and metastasis. Herein we document the molecular characteristics and functions of MALAT1 with a reference to their implications in the molecular pathology of various cancers.
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