Research progress on the role of AMPK signaling pathway in the development of nonalcoholic fatty liver disease
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摘要:
腺苷酸活化蛋白激酶（AMP-activated protein kinase，AMPK）是细胞的“能量感受器”，具有调控和维持能量动态平衡的作用，激活的AMPK可以抑制肝内甘油三酯、糖异生、胆固醇和脂肪酸的合成代谢。非酒精性脂肪肝病（nonalcoholic fatty liver disease，NAFLD）已成为我国最常见的慢性肝病之一，其发病机制复杂，胰岛素抵抗（insulin resistance，IR）、氧化应激等可能是其发病的关键因素，而AMPK的活化可作用于这些因素从而改善NAFLD。文章就AMPK信号通路如何在NAFLD的发生中发挥作用简要进行综述。
Abstract:
AMP-activated protein kinase is the cellular energy sensor. It has the function of regulating and maintaining energy dynamic balance. Activated AMPK inhibits the synthesis and metabolism of triglycerides，gluconeogenesis，cholesterol and fatty acids in the liver. Nonalcoholic fatty liver disease has become one of the most common chronic liver diseases in China. Its pathogenesis is complicated，insulin resistance and oxidative stress may account for a key factor. Other factors may involve leptin，adiponectin，resistin，tumor necrosis factor，etc. The activation of AMPK may affect these risk factors and improve NAFLD. We aim to describe how AMPK plays a role in the occurrence of NAFLD.
