文章摘要
吴 鑫,钱焱霞,庞斯斯,徐 冰,王俊宏.血浆脂蛋白相关磷脂酶A2与急性心肌梗死患者心功能的相关性研究[J].南京医科大学学报,2019,(10):1437~1441
血浆脂蛋白相关磷脂酶A2与急性心肌梗死患者心功能的相关性研究
Relationship between concentration of plasma Lp-PLA2 and cardiac function after acute myocardial infarction
投稿时间:2019-06-25  
DOI:10.7655/NYDXBNS20191006
中文关键词: 急性心肌梗死  脂蛋白相关磷脂酶A2  左室射血分数
英文关键词: acute myocardial infarction  lipoprotein⁃associated phospholipase A2  left ventricular ejection fraction
基金项目:国家自然科学基金面上项目(81570328);江苏省医学重点人才项目(ZDRCB2016005)
作者单位
吴 鑫 南京医科大学第一附属医院产科实验室江苏 南京 210029 
钱焱霞 南京医科大学第一附属医院心脏科江苏 南京 210029 
庞斯斯 南京医科大学第一附属医院老年心脏科江苏 南京 210029 
徐 冰 苏北人民医院心脏科江苏 扬州 225001 
王俊宏 南京医科大学第一附属医院心脏科江苏 南京 210029 
摘要点击次数: 29
全文下载次数: 19
中文摘要:
      目的:研究急性心肌梗死患者血浆脂蛋白相关磷脂酶A2(Lp?PLA2)浓度变化情况及其与心肌梗死后心功能的相关性。方法:连续入选急性心肌梗死患者90例,测定患者入院即刻(T0)、入院次日(T1)、入院第3天(T2)和入院第7天(T3)血浆Lp?PLA2及心梗后1个月(T4)N端前体脑钠肽(NT?proBNP)水平,并采用二维心脏超声测定T1和T4患者左室射血分数(LVEF),Pearson相关分析Lp?PLA2与LVEF及NT?proBNP的相关性。以43例同期入院稳定性心绞痛患者和48例健康体检者作为对照。结果:急性心肌梗死患者血浆Lp?PLA2水平呈动态改变,心梗发作时显著增高,而入院第7天后基本降至对照组水平[(61.42±36.99)mg/L vs.(49.83±27.17)mg/L,P > 0.05]。相关性分析显示入院即刻(T0)血浆Lp?PLA2水平与C反应蛋白水平(r=0.06,P > 0.05)及血浆肌钙蛋白T水平(r=-0.07,P > 0.05)均无显著相关性。进一步研究发现入院时(T0)血浆Lp?PLA2水平与T4血浆NT?proBNP水平(P=0.16,P > 0.05)、左室射血分数(LVEF)(r=-0.09,P > 0.05)及T4与T1 LVEF差值(ΔLVEF)(r=0.04,P > 0.05)均无显著相关性。结论:血浆Lp?PLA2水平反映了急性心肌梗死动脉斑块不稳定状态,但与急性心肌梗死患者梗死后心功能恢复情况无关。
英文摘要:
      Objective:To study the change of plasma lipoprotein?associated phospholipase A2(Lp?PLA2)concentration in patients with acute myocardial infarction(AMI)and its correlation with cardiac function after AMI. Methods:Ninety consecutive AMI patients who met the study criteria were enrolled. The plasma Lp?PLA2 levels were measured immediately after admission(T0),the next day(T1),the third day(T2),and the seventh day(T3),N?terminal pro brain natriuretic peptide(NT?proBNP)was measured one month after AMI(T4),left ventricular ejection fraction(LVEF)was measured by two?dimensional echocardiography at T1 and T4. Pearson correlation analysis was used to analyze the correlation between Lp?PLA2 and LVEF or NT?proBNP. In addition,48 healthy volunteers and 43 stable angina pectoris patients were enrolled as the controls. Results:The level of plasma Lp?PLA2 showed dynamic changes after AMI,it was increased significantly after the onset of the disease,but decreased to normal level after 7th days of admission[(61.42±36.99)mg/L vs.(49.83±27.17)mg/L,P > 0.05]. The correlation analysis showed that there was no significant correlation between on?admission plasma Lp?PLA2 and C?reactive protein level(r=0.06,P > 0.05)or between Lp?PLA2 and cardiac troponin T level(r=-0.07,P > 0.05). Further studies showed that there was no significant correlation between plasma Lp?PLA2 level at T0 and plasma NT?proBNP level at T4(r=0.16,P > 0.05)or LVEF at T4(r=-0.09,P > 0.05)or the difference of LVEF between T1 and T4(r=0.04,P > 0.05). Conclusion:The plasma level of Lp?PLA2 showed dynamic changes after AMI,which reflected the unstable state of artery plaques,but it was not related to the recovery of cardiac function after AMI.
查看全文   查看/发表评论  下载PDF阅读器
关闭