文章摘要
戴正泽,黎宏斐,戴柔丽,洪 潇.中性粒⁃淋巴细胞比值与脑白质疏松相关[J].南京医科大学学报,2019,(10):1476~1479
中性粒⁃淋巴细胞比值与脑白质疏松相关
Clinical significance of high⁃risk HPV E6/E7 mRNA test in patients with HPV infection
投稿时间:2019-07-25  
DOI:10.7655/NYDXBNS20191014
中文关键词: 脑白质疏松  高血压  中性粒⁃淋巴细胞比值  危险因素
英文关键词: HR⁃HPV E6/E7 mRNA test  HPVDNA test  clinical value
基金项目:南京市医学科技发展基金(YKK18232)
作者单位
戴正泽 南京市浦口医院神经内科江苏 南京 210031 
黎宏斐 南京市浦口医院神经内科江苏 南京 210031 
戴柔丽 南京市浦口医院药剂科江苏 南京 210031 
洪 潇 苏州大学第一附属医院药剂科江苏 苏州 215006 
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中文摘要:
      目的:探讨脑白质疏松(leukoaraiosis,LA)的相关危险因素。方法:回顾性收集110例住院患者临床资料,所有患者均接受核磁共振检查,应用液体衰减恢复序列检查LA,根据Fazekas量表评估其严重程度,采用Logistic回归分析方法确定LA的危险因素。结果:110例患者中59例患者表现为无~轻度LA,51例表现为中~重度LA。多因素回归分析示年龄(OR=1.07,95%CI:1.02~1.12,P=0.003)、高血压(OR=2.51,95%CI:1.03~6.14,P=0.043)、中性粒?淋巴细胞比值(OR=1.34,95%CI:1.02~1.76,P=0.039)和中性粒细胞计数(P=0.010)与LA相关。结论:年龄、高血压、中性粒?淋巴细胞比值和中性粒细胞计数是LA的独立危险因素。
英文摘要:
      Objective:To investigate the clinical value and significance of high risk human papilloma virus(HPV)E6/E7 mRNA test in patients with HPV infection. Methods:Between January 2017 and June 2017,in Center of Diagnosis and Treatment for Cervical Disease,200 patients with HPV infection in cervical screening received high?risk HPV E6/E7 mRNA test and pathological biopsy under colposcopy. We analyzed the E6/E7 mRNA detection rate of positive cases,and the E6/E7mRNA expression in different pathological diagnosis. Results:The E6/E7 mRNA detection rate was 60% in the 200 patients. The highest E6/E7 mRNA positive expression in the high?grade squamous intraepithelial lesion group(HSIL)had significant differences with the low?grade squamous intraepithelial lesion group(LSIL)and the nomal group. The mRNA sensitivity was 97.9% and negative predictive value was 98.8%(P < 0.05). The sensitivity,specificity,positive predictive value and negative predictive value were lower in the LSIL group. Conclusion:We could shunt the patients with HPV infection,avoid excessive treatment and reduce the patient’s psychological burden byHR?HPV E6/E7 mRNA test. High?risk HPV E6/E7 mRNA test has high clinical value in diagnosis of HSIL during cervical screening.
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