文章摘要
黄 婷,龚晨辉,叶水文,余 玲,周 芬,饶美英.危重症患者限制性输血策略的临床效果分析[J].南京医科大学学报,2019,(10):1480~1482
危重症患者限制性输血策略的临床效果分析
Expression and role of serum stanniocalcin⁃1 in chronic obstructive pulmonary disease
投稿时间:2019-06-12  
DOI:10.7655/NYDXBNS20191015
中文关键词: 重症监护  输血策略  限制性输血  开放性输血  临床效果
英文关键词: chronic obstructive pulmonary disease(COPD)  stanniocalcin⁃1(STC1)
基金项目:江西省教育厅科技技术研究青年项目(170144)
作者单位
黄 婷 南昌大学第二附属医院输血科江西 南昌 330006 
龚晨辉 南昌大学第二附属医院输血科江西 南昌 330006 
叶水文 南昌大学第二附属医院输血科江西 南昌 330006 
余 玲 南昌大学第二附属医院输血科江西 南昌 330006 
周 芬 南昌大学第二附属医院输血科江西 南昌 330006 
饶美英 南昌大学第二附属医院输血科江西 南昌 330006 
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中文摘要:
      目的:评价危重症患者限制性输血与开放性输血的临床治疗效果。方法:回顾性分析南昌大学第二附属医院ICU 2017年8月—2018年7月进行红细胞输血治疗的危重症患者共101例,比较两种输血策略的临床治疗效果。结果:限制性输血组输血前血红蛋白(hemoglobin,Hb)值、输血后Hb值及红细胞输注量均明显低于开放性输血组水平(P < 0.05);限制性输血组的多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)评分、≥3个衰竭器官数及肺水肿发生率、心力衰竭发生率均低于开放性输血组(P < 0.05);临床转归方面,两组病死率和重症感染发生率的差异均无统计学意义(P > 0.05)。结论:ICU贫血患者限制性输血策略的临床效果优于开放性输血策略。
英文摘要:
      Objective:To investigate the serum level of stanniocalcin?1(STC1) in patients with stable chronic obstructive pulmonary diseases(COPD) and to explore the relationship between STC1 and severity of the disease. Method:A total of 55 patients with definite stable COPD and 24 healthy controls were enrolled in this study. Serum STC1 was measured by enzyme?linked immunosorbent assay(ELISA),and the correlation between STC1 and COPD was analyzed. Results:①Serum STC1 levels were significantly lower in patients with COPD than healthy controls(P < 0.05). ②The receiver?operating characteristic(ROC) curve of serum SCT1 was used for threshold identification(AUC=0.659,P=0.025),the optimal cut?off point of serum STC1 was 1 350 pg/mL(sensitivity 81.82%,specificity 50.00%,respectively). ③Poor association of serum STC1 levels with stable COPD was found,including the GOLD classification,COPD assessment test(CAT) scores and lung functions. Conclusion:Serum STC1 levels were significantly decreased in COPD patients while it is poorly correlated with disease severity. STC1 might have clinical application in stable COPD.
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