文章摘要
龚红蕾,徐 坚,陈尚明.儿童难治性肾病诊疗体会[J].南京医科大学学报,2019,(10):1483~1485
儿童难治性肾病诊疗体会
Serum miR⁃21 expression level in infant respiratory distress syndrome
投稿时间:2019-05-05  
DOI:10.7655/NYDXBNS20191016
中文关键词: 难治性肾病  IgA肾病  膜性肾病  甲基强的松龙  他克莫司
英文关键词: miR⁃21  infant respiratory distress syndrome  premature infant
基金项目:国家自然科学基金青年基金(81300023,81300521);江苏省自然科学基金青年基金 (BK20131020);江苏高校优势学科建设工程(JX10231081);江苏省妇幼保健重点学科(FXK 201730)
作者单位
龚红蕾 南通大学附属医院儿科江苏 南通 226001 
徐 坚 南通大学附属医院儿科江苏 南通 226001 
陈尚明 南通大学附属医院儿科江苏 南通 226001 
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中文摘要:
      目的:总结分析儿童难治性肾病的诊疗技术,以提高难治性肾病的诊治水平。方法:回顾性分析2009年1月—2019年6月南通大学附属医院就诊的儿童难治性肾病30例患者资料,包括临床检测指标、治疗经过和预后情况。结果:30例难治性肾病患儿均口服泼尼松治疗,其中耐药25例,复发5例。经甲泼尼龙、盐酸贝那普利及百灵、黄葵等中药治疗后,17例尿蛋白转阴,另外13例尿蛋白未转阴,加用其他免疫抑制剂。使用甲泼尼龙治疗尿蛋白转阴患儿临床及病理类型比加用其他免疫抑制剂患儿复杂。甲泼尼龙主要不良反应有高血压、窦性心动过速或过缓以及感染,他克莫司等免疫抑制剂主要不良反应有感染、高血糖、个别高尿酸血症。结论:难治性肾病应及早进行肾活检,积极治疗。目前主张使用激素或者联合其他免疫抑制剂多靶点治疗,辅助百灵、黄葵、血管紧张素转换酶抑制剂或血管紧张素转换酶受体抑制剂可取得较好效果。
英文摘要:
      Objective:To determine the pathological significance of serum miR?21 expression level in premature respiratory distress syndrome(RDS)infants. Methods:Randomized blood samples were collected from RDS and non?RDS infants in the Neonatal Intensive Care Unit(NICU)of Jiangsu Province Hospital from June to December 2015. Total RNA was extracted from each blood sample and reverse transcribed into complementary DNA(cDNA). We used real?time reverse transcription polymerase chain reaction(RT?PCR)technique to determine the serum miR?21 expression levels in the RDS and the non?RDS groups(n=30 and n=21,respectively). Unpaired student t?test was used to compare the significance between groups. Results:The serum miR?21 expression level in the RDS group was significantly higher than that in the control group(P < 0.05). The miR?21 expression levels in the moderate to severe RDS groups appeared to be higher than that in the mild groups,however,statistic significance was not reached in our study. In addition,the RDS group that received pulmonary surfactant therapy had significant increase in miR?21 expression levels(P < 0.05). Conclusion:Serum miR?21 expression level is closely related to the development of infant RDS,suggesting that miR?21 is involved in the pathogenesis of infant RDS.
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