文章摘要
戴东方,陈德玉,李小琴,顾汉刚,陶 清,王德强.切除修复交叉互补酶1等常见耐药相关蛋白在伴神经侵犯胃癌中的表达[J].南京医科大学学报,2019,(11):1584~1588
切除修复交叉互补酶1等常见耐药相关蛋白在伴神经侵犯胃癌中的表达
Expression of chemotherapy resistance associated proteins including excision repair cross⁃complementation group 1 in gastric cancer patients with perineural invasion
投稿时间:2019-04-15  
DOI:10.7655/NYDXBNS20191107
中文关键词: 胃癌  神经侵犯  切除修复交叉互补酶1
英文关键词: gastric cancer  perineural invasion  excision repair cross⁃complementation group 1
基金项目:国家自然科学基金资助项目(81301765);江苏省青年医学重点人才项目(QNRC2016829);镇江市科技计划项目(SH2015054,SH2016038);江苏大学附属医院“5123”人才计划(51232017301)
作者单位
戴东方 江苏大学附属医院肿瘤科江苏 镇江 212001 
陈德玉 江苏大学附属医院肿瘤科江苏 镇江 212001 
李小琴 江苏大学附属医院肿瘤科江苏 镇江 212001 
顾汉刚 江苏大学附属医院肿瘤科江苏 镇江 212001 
陶 清 江苏大学附属医院肿瘤科江苏 镇江 212001 
王德强 江苏大学附属医院肿瘤科江苏 镇江 212001 
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中文摘要:
      目的:检测切除修复交叉互补酶1(excision repair cross?complementation group 1,ERCC1)等常见耐药相关蛋白在伴神经侵犯胃癌患者中的表达。方法:回顾性分析242例胃腺癌患者的临床资料,免疫组化染色检测肿瘤组织中ERCC1、微管蛋白β3、胸苷酸合酶(thymidylate synthase,TS)、DNA拓扑异构酶2(topoisomerase 2?alpha,TOP2A)及P 糖蛋白的蛋白表达水平,比较有和无神经侵犯者上述分子标志物表达的差异。结果:108例(44.6%)有神经侵犯,其肿瘤最大径≥5 cm、低分化、伴肿瘤脉管侵犯及TNM分期Ⅲ~Ⅳ期的比例均显著高于无神经侵犯者(P < 0.05)。伴神经侵犯者的ERCC1高表达率显著高于无神经侵犯者(63.9% vs. 46.5%,P < 0.05),而其他耐药相关蛋白的高表达率在两组间均无统计学差异(P > 0.05)。亚组分析显示,有和无神经侵犯者之间ERCC1高表达率的差异主要出现于男性(64.8% vs. 43.1%,P=0.026)和肿瘤低分化的患者中(76.3% vs. 42.9%,P=0.006)。结论:伴神经侵犯胃癌患者的ERCC1蛋白表达水平升高,提示了神经侵犯影响化疗疗效的可能原因。
英文摘要:
      Objective:To investigate the expressions of proteins associated with chemotherapy resistance including excision repair cross?complementation group 1(ERCC1) in gastric cancer patients perineural invasion(PNI). Methods:A retrospective study was conducted in 242 patients with gastric adenocarcinoma. The expressions of tubulin β3,thymidylate synthase(TS),P?glycoprotein,topoisomerase 2?alpha(TOP2A) and ERCC1 were detected by immunohistochemistry in paraffin?embedded tumor tissues and were compared between patients with and without PNI. Results:PNI was detected in 108 patients(44.6%),and the proportions of patients with the longest diameter of tumor ≥5 cm,poor histological differentiation,lymphovascular invasion and TNM stages of Ⅲ~Ⅳ were significantly higher in these patients than those in patients without PNI(P < 0.05). The high expression rate of ERCC1 in patients with PNI was significantly higher than those in those without PNI(63.9% vs. 46.5%,P < 0.05),and this difference was mainly found in subgroups of male(64.8% vs. 43.1%,P=0.026) and poor differentiation(76.3% vs. 42.9%,P=0.006). The high expression rates of tubulin β3,TS,P?glycoprotein and TOP2A were not significantly different between these two groups(P > 0.05). Conclusion:Gastric cancer patients with PNI had an increased expression level of ERCC1 protein,indicating the possible mechanism of poor chemotherapy effect induced by PNI.
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