文章摘要
武正山,刘一纬,吴晓峰.肝癌组织CCR1表达与患者预后的关系[J].南京医科大学学报,2019,(12):1737~1740
肝癌组织CCR1表达与患者预后的关系
The relationship of CCR1 expression in hepatocellular carcinoma tissue and the prognosis of patients
投稿时间:2019-06-03  
DOI:10.7655/NYDXBNS20191206
中文关键词: 肝细胞癌  CCR1  组织芯片  免疫组织化学  预后
英文关键词: hepatocellular carcinoma  CCR1  tissue microarray  immunohistochemistry  prognosis
基金项目:国家自然科学基金(81472306)
作者单位
武正山 南京医科大学第一附属医院肝胆中心江苏 南京 210029 
刘一纬 南京医科大学第一附属医院肝胆中心江苏 南京 210029 
吴晓峰 南京医科大学第一附属医院肝胆中心江苏 南京 210029 
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中文摘要:
      目的:研究CC趋化因子受体1(C?C motif chemokine receptor 1,CCR1)蛋白在人肝细胞癌(hepatocellular carcinoma,HCC)中的表达及与临床病理因素和预后的相关性。方法:构建288例HCC组织芯片,应用免疫组化(三步法)检测288例HCC组织中CCR1蛋白的表达情况,对随访资料作单因素和多因素相关生存分析。结果:CCR1在HCC组织中的表达显著高于癌旁组织,CCR1阳性组的无瘤生存期和总体生存期显著低于阴性组。多因素分析显示CCR1阳性是HCC术后无瘤生存期和总体生存期的独立危险因素。结论:检测HCC中CCR1的表达水平有助于术后复发的预测。
英文摘要:
      Objective:This study aims to investigate the expression of C ?C motif chemokine receptor 1(CCR1)protein in human hepatocellular carcinoma(HCC)and its correlation with clinicopathological factors and prognosis. Methods:Immunohistochemistry (three ? step method)was used to detect the expression of CCR1 protein in tissue microarray constructed by 288 cases of HCC. Univariate and multivariate Cox regression models were performed on follow?up data. Results:The expression of CCR1 in HCC tissues was significantly higher than that in adjacent tissues. The tumor?free survival and overall survival of CCR1 positive expression group were significantly lower than those of CCR1 negative expression group. Multivariate Cox regression models showed that positive expression of CCR1 was an independent risk factor for tumor?free survival and overall survival after surgery. Conclusion:Detection of CCR1 expression in HCC is helpful for the prediction of postoperative recurrence
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