文章摘要
高其忠,刘 芬,高 翔,葛晓松.高表达ZNF692是胃癌患者不良预后的预测因子[J].南京医科大学学报,2019,(12):1747~1750
高表达ZNF692是胃癌患者不良预后的预测因子
High expression of ZNF692 is a predictor of poor prognosis in patients with gastric cancer
投稿时间:2019-06-07  
DOI:10.7655/NYDXBNS20191208
中文关键词: ZNF692  胃癌  预后
英文关键词: ZNF692  gastric cancer  prognosis
基金项目:国家自然基金青年项目(81502042);无锡市“科教强卫工程”?无锡市医学重点人才(ZDRC008);无锡市卫计委卫生科研项目(Q201731)
作者单位
高其忠 江南大学附属医院胃肠外科江苏 无锡 214062 
刘 芬 江南大学附属医院肿瘤研究所江苏 无锡 214062 
高 翔 江南大学附属医院胃肠外科江苏 无锡 214062 
葛晓松 江南大学附属医院胃肠外科江苏 无锡 214062 
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中文摘要:
      目的:探讨锌指蛋白692(Zinc finger protein 692,ZNF692)是否可以作为胃癌患者不良预后的独立预测因子。方法:采用免疫组化染色法检测191例胃癌组织及其癌旁组织中ZNF692的表达水平。结果:ZNF692在胃癌组织中的表达显著高于癌旁组织。ZNF692高表达患者与ZNF692低表达患者的临床病理学特征差异无统计学意义(P>0.05)。ZNF692高表达患者总生存期(overall survival,OS)低于ZNF692低表达患者,差异有统计学意义(P=0.000 1)。ZNF692高表达患者平均生存期(30.1个月)短于ZNF692低表达患者(42.6个月),差异有统计学意义(P <0.01)。Cox多因素风险回归模型分析显示,ZNF692可以作为胃癌患者不良预后的独立预测因子。结论:高表达ZNF692是胃癌患者不良预后的预测因子之一。
英文摘要:
      Objective:This study aims to investigate whether Zinc finger protein 692(ZNF692)can be used as an independent predictor of poor prognosis in patients with gastric cancer. Methods:Immunohistochemical(IHC)staining was used to detect the expression of ZNF692 in gastric cancer tissues and adjacent tissues of 191 cases. Results:The expression of ZNF692 in gastric cancer tissues was significantly higher than that in adjacent tissues. There was no significant difference in the clinicopathological features between patients with high ZNF692 expression and those with low ZNF692 expression(P > 0.05). However,overall survival(OS)of patients with ZNF692 high expression was significantly shorter than that of patients with ZNF692 low expression(P=0.000 1). The mean survival time of patients with ZNF692 high expression(30.1 months)was significantly shorter than that of patients with ZNF692 low expression(42.6 months)(P < 0.01). Cox multivariate risk regression model analysis showed that ZNF692 could be used as an independent predictor of poor prognosis in patients with gastric cancer. Conclusion:High expression of ZNF692 is one of poor prognosis predictors in patients with gastric cancer.
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