高表达ZNF692是胃癌患者不良预后的预测因子
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国家自然基金青年项目(81502042);无锡市“科教强卫工程”?无锡市医学重点人才(ZDRC008);无锡市卫计委卫生科研项目(Q201731)


High expression of ZNF692 is a predictor of poor prognosis in patients with gastric cancer
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    摘要:

    目的:探讨锌指蛋白692(Zinc finger protein 692,ZNF692)是否可以作为胃癌患者不良预后的独立预测因子。方法:采用免疫组化染色法检测191例胃癌组织及其癌旁组织中ZNF692的表达水平。结果:ZNF692在胃癌组织中的表达显著高于癌旁组织。ZNF692高表达患者与ZNF692低表达患者的临床病理学特征差异无统计学意义(P>0.05)。ZNF692高表达患者总生存期(overall survival,OS)低于ZNF692低表达患者,差异有统计学意义(P=0.000 1)。ZNF692高表达患者平均生存期(30.1个月)短于ZNF692低表达患者(42.6个月),差异有统计学意义(P <0.01)。Cox多因素风险回归模型分析显示,ZNF692可以作为胃癌患者不良预后的独立预测因子。结论:高表达ZNF692是胃癌患者不良预后的预测因子之一。

    Abstract:

    Objective:This study aims to investigate whether Zinc finger protein 692(ZNF692)can be used as an independent predictor of poor prognosis in patients with gastric cancer. Methods:Immunohistochemical(IHC)staining was used to detect the expression of ZNF692 in gastric cancer tissues and adjacent tissues of 191 cases. Results:The expression of ZNF692 in gastric cancer tissues was significantly higher than that in adjacent tissues. There was no significant difference in the clinicopathological features between patients with high ZNF692 expression and those with low ZNF692 expression(P > 0.05). However,overall survival(OS)of patients with ZNF692 high expression was significantly shorter than that of patients with ZNF692 low expression(P=0.000 1). The mean survival time of patients with ZNF692 high expression(30.1 months)was significantly shorter than that of patients with ZNF692 low expression(42.6 months)(P < 0.01). Cox multivariate risk regression model analysis showed that ZNF692 could be used as an independent predictor of poor prognosis in patients with gastric cancer. Conclusion:High expression of ZNF692 is one of poor prognosis predictors in patients with gastric cancer.

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高其忠,刘 芬,高 翔,葛晓松.高表达ZNF692是胃癌患者不良预后的预测因子[J].南京医科大学学报(自然科学版),2019,(12):1747-1750

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  • 收稿日期:2019-06-07
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  • 在线发布日期: 2020-01-09
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