易感基因HLA⁃B*35及其亚型在中国大陆的分布
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江苏省卫生厅面上项目(Z201401)


Distribution of HLA⁃B*35 high resulaton type in subacute thyroiditis in mainland China
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    摘要:

    目的:明确易感基因HLA-B*35及其亚型在中国大陆人群总体及区域分布情况,以期为相关疾病,尤其是亚急性甲状腺炎的诊断和鉴别诊断提供参考。方法:中国大陆941 902例健康成人经HLA基因高分辨分型并按31个省市、自治区、直辖市进行分层,以探讨中国大陆健康成人及其HLA-B*35基因和其亚型总体和地区分布特征。结果:中国大陆健康成人群体HLA-B*35基因阳性率呈现北方人群高于其他地区人群;按地区分类,西北地区的HLA-B*35基因阳性率最高,华南地区阳性率较低;按省市自治区分别计算,阳性率由高到低排列分别为内蒙古自治区(11.99%)、新疆维吾尔自治区(11.76%)、宁夏回族自治区(11.75%)、青海省(11.61%)、甘肃省(11.14%),阳性率最低为广西壮族自治区(3.79%);HLA-B*3501和B*3503按地区分类时为西北最高,华南最低;按省市自治区分别统计,显示B*3501内蒙古自治区最高而广西壮族自治区最低,B*3503则表现为青海省最高,浙江省最低。结论:HLA-B*35在中国大陆地区呈现北高南低,不同地区B*35及其亚型分布,结果有助于相关疾病诊断及鉴别诊断。

    Abstract:

    Objective:The aim of this study was to provide the reference for the diagnosis and differential diagnosis of related diseases,especially subacute thyroiditis by determining the general and regional distribution of the susceptible gene HLA-B*35 and its subtypes in Chinese mainland. Method:HLA high resolution typing was performed in 941 902 healthy adults in China. By classifing into 31 provinces,autonomous regions and municipalities,the overall and regional distribution characteristics of healthy adults and their HLA-B*35 genes and their subtypes in mainland China were determined. Results:The frequency of HLA-B *35 gene in healthy adult population in mainland China was higher in the northern population than that in the other regions. According to the classification of regions,the frequency of HLA-B *35 gene was the highest in Northwest China and was lower in South China. According to the calculation of provinces,municipalities and autonomous regions,the results showed that the gene frequency ranged from high to low in Inner Mongolia Autonomous Region(11.99%),Xinjiang Uygur Autonomous Region(11.76%),Ningxia Hui Autonomous Region(11.75%),Qinghai Province(11.61%)and Gansu Province(11.14%). The lowest frequency was in Guangxi Zhuang Autonomous Region(3.79%). The frequency of HLA-B* 3501 and HLA-B*3503 were the highest in Northwest China and the lowest in South China when classified by region. According to statistics of provinces and autonomous regions,the frequency of B*3501 is the highest in Inner Mongolia autonomous region and the lowest in Guangxi Zhuang autonomous region. Correspondingly,the frequency of B*3503 is the highest in Qinghai province and the lowest in Zhejiang province. Conclusion:The results showed that the distribution of HLA-B *35 in mainland China was high in the north and low in the south. Our study was conducted to explore the distribution of HLA-B*35 and its subtypes in different regions which is helpful for the diagnosis and differential diagnosis of related diseases.

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樊 甦,马 骁,潘芹芹,王晓艳,张志欣,蔡剑平,毛 伟,王振雷,陈 强,李剑平,张德梅,刘 琪,吴宝红,沈 捷.易感基因HLA⁃B*35及其亚型在中国大陆的分布[J].南京医科大学学报(自然科学版),2020,(2):210-216

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  • 收稿日期:2019-06-30
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  • 在线发布日期: 2020-03-14
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