文章摘要
潘必慧,孔祎琳,王 莉,朱华渊,徐 卫.C反应蛋白/白蛋白比值在弥漫大B细胞淋巴瘤患者中的预后价值[J].南京医科大学学报,2020,(2):228~233
C反应蛋白/白蛋白比值在弥漫大B细胞淋巴瘤患者中的预后价值
Prognostic value of C⁃reactive protein⁃to⁃albumin ratio in diagnosed diffuse large B⁃cell lymphoma
投稿时间:2019-09-13  
DOI:10.7655/NYDXBNS20200215
中文关键词: 弥漫大B细胞淋巴瘤  C反应蛋白/白蛋白比值  预后
英文关键词: diffuse large B⁃cell lymphoma  C⁃reactive protein⁃to⁃albumin ratio  prognosis
基金项目:国家自然科学基金(81770166)
作者单位
潘必慧 南京医科大学第一附属医院血液科 江苏 南京 210029 
孔祎琳 南京医科大学第一附属医院血液科 江苏 南京 210029 
王 莉 南京医科大学第一附属医院血液科 江苏 南京 210029 
朱华渊 南京医科大学第一附属医院血液科 江苏 南京 210029 
徐 卫 南京医科大学第一附属医院血液科 江苏 南京 210029 
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中文摘要:
      目的:探究C反应蛋白/白蛋白比值(C?reactive protein?to?albumin ratio,CAR)在弥漫大B细胞淋巴瘤(diffuse large B?cell lymphoma,DLBCL)中的预后价值。方法:回顾性分析南京医科大学第一附属医院2009年12月—2018年12月收治的初诊DLBCL患者的临床资料。使用Kaplan?Meier方法分析影响无进展生存期(progression?free survival,PFS)和总生存期(overall survival,OS)的因素,使用Cox比例风险回归模型进行单变量及多变量分析。结果:314例患者纳入分析,截至2019年6月,中位随访50个月,中位PFS和OS均未达到。生存分析显示CAR增高具有更差的PFS和OS(P均<0.001),且CAR是影响PFS(P=0.006)及OS(P=0.009)的独立预后因素。此外,将CAR与美国国家综合癌症网络国际预后指数(National Comprehensive Cancer Network International Prognostic Index,NCCN?IPI)结合后对DLBCL的PFS和OS的预测和判别能力优于NCCN?IPI(P=0.010和P=0.002)。结论:CAR为简单易行的参数,可作为预测DLBCL临床预后的良好指标。
英文摘要:
      Objective:This study aims to explore the prognostic value of C?reactive protein?to?albumin(CRP/ALB)ratio(CAR)in diagnosed diffuse large B?cell lymphoma(DLBCL). Methods:The clinical data of newly diagnosed DLBCL patients diagnosed in the First Affiliated Hospital of Nanjing Medical University between December 2009 and December 2018 were analyzed retrospectively. Progression?free survival (PFS) and overall survival (OS) were calculated by Kaplan?Meier method. Cox proportional hazards models were used for the univariate and multivariate analysis. Results:A total 314 newly diagnosed DLBCL patients were enrolled in the study. Up to June 2019,median follow up time was 50 months,and the median PFS and OS were unreached. Patients with higher CAR had shorter PFS and OS(P < 0.001). The multivariate analysis strongly demonstrates that CAR is an independent predictor for both PFS(P=0.006)and OS(P=0.009). Furthermore,the predictive and discriminatory capacity of National Comprehensive Cancer Network International Prognostic Index(NCCN?IPI)together with CAR level was superior to alone for PFS(P=0.010)and OS(P=0.002). Conclusion:CAR is a simple and easily accessible parameter,which may be a good candidate for predicting prognosis of DLBCL.
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