文章摘要
王宏刚,杨晓钟,吴尚农,戴伟杰,马天恒,谢 睿,沈 鹏,李倩君.冠状病毒相关基因在IBD肠黏膜组织中的表达与COVID⁃19患病风险的相关性研究[J].南京医科大学学报,2020,(6):788~792
冠状病毒相关基因在IBD肠黏膜组织中的表达与COVID⁃19患病风险的相关性研究
Correlation between the expression of coronavirus⁃related genes in the intestinal mucosa of IBD and the risk of COVID⁃19
投稿时间:2020-03-13  
DOI:10.7655/NYDXBNS20200603
中文关键词: 新型冠状病毒  COVID⁃19  炎症性肠病  基因  肠黏膜
英文关键词: SARS⁃CoV⁃2  COVID⁃19  inflammatory bowel disease  gene  intestinal mucosa
基金项目:江苏省卫生健康委科研课题(H2018082);淮安市自然科学研究计划课题(HAB201926);淮安市第一人民医院转化医学创新团队科研项目(YZHT201905)
作者单位
王宏刚 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
杨晓钟 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
吴尚农 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
戴伟杰 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
马天恒 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
谢 睿 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
沈 鹏 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
李倩君 南京医科大学附属淮安第一医院消化科江苏 淮安 223300 
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中文摘要:
      目的:分析炎症性肠病(inflammatory bowel disease,IBD)患者肠黏膜的冠状病毒相关基因[血管紧张素转换酶2(angiotensin?converting enzyme 2,ACE2)、跨膜丝氨酸蛋白酶2(transmembrane protease serine 2,TMPRSS2)、二肽基肽酶4(dipeptidyl peptidase 4,DPP4)、氨基肽酶N(aminopeptidase N,ANPEP)]的表达差异。方法:收集新型冠状病毒肺炎(corona virus disease 2019,COVID?19)患者的腹泻发生率,并且利用IBDMDB数据库,分析IBD患者肠黏膜ACE2、TMPRSS2、DPP4、ANPEP的表达差异。结果:COVID?19患者的腹泻发生率为5.8%(136/2 350)。与直肠黏膜相比,末端回肠ACE2、TMPRSS2、DPP4、ANPEP的差异表达倍数分别为9.800、0.571、5.318和11.127倍,差异有统计学意义(P < 0.05)。但这4种基因的表达在IBD与非IBD患者中未显示出显著差异(P > 0.05)。GO分类显示这些基因都参与了病毒进入宿主细胞的生物学过程,且各基因之间有相互作用。结论:冠状病毒相关基因(ACE2、TMPRSS2、DPP4、ANPEP)在IBD与非IBD的肠黏膜组织中的表达没有显著差异,推测IBD没有显著增加COVID?19的患病风险。
英文摘要:
      Objective:The aim of this study was to analyze the expression of coronavirus?associated genes[angiotensin?converting enzyme 2(ACE2),transmembrane protease serine 2(TMPRSS2),dipeptidyl peptidase 4(DPP4),aminopeptidase N(ANPEP)]in the intestinal mucosa of patients with inflammatory bowel disease(IBD). Methods:The occurrence of diarrhea in patients with corona virus disease 2019(COVID?19)were collected,and the IBDMDB database was used to analyze the expression of ACE2,TMPRSS2,DPP4 and ANPEP in the intestinal mucosa of IBD patients. Results:The occurrence of diarrhea in COVID?19 patients was 5.8%(136/2 350). Compared with the rectal mucosa,the difference expression fold of ACE2,TMPRSS2,DPP4 and ANPEP in the terminal ileum were 9.800,0.571,5.318 and 11.127,respectively,with statistical differences(P < 0.05). However,the expression of these 4 genes did not show significant differences between IBD and non?IBD patients(P > 0.05). The GO classification showed that these genes were involved in the biological process of the virus entering the host cell,and there was a network interaction between these genes. Conclusion:There is no significant difference in the expression of coronavirus?related genes(ACE2,TMPRSS2,DPP4,ANPEP) in the intestinal mucosa of IBD and non?IBD. We speculate that IBD patients do not have a significantly increased risk of COVID?19.
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