文章摘要
许洪磊,张 望,陈 亮,闻 伟,王 俊,徐心峰,朱 全.离体动物肺段切除术模型的建立[J].南京医科大学学报,2020,(6):826~831
离体动物肺段切除术模型的建立
Establishment of segmentectomy model in ex vivo animals
投稿时间:2019-12-27  
DOI:10.7655/NYDXBNS20200610
中文关键词: 肺段切除术  解剖  动物模型  段间交界面  肺漏气
英文关键词: segmentectomy:anatomy:animal model:intersegmental plane:pulmonary air leakage
基金项目:江苏省科技厅重点研发计划(社会发展)项目(BE2016790)
作者单位
许洪磊 南京医科大学第一附属医院胸外科江苏 南京 210029 
张 望 南京医科大学第一附属医院胸外科江苏 南京 210029 
陈 亮 南京医科大学第一附属医院胸外科江苏 南京 210029 
闻 伟 南京医科大学第一附属医院胸外科江苏 南京 210029 
王 俊 南京医科大学第一附属医院胸外科江苏 南京 210029 
徐心峰 南京医科大学第一附属医院胸外科江苏 南京 210029 
朱 全 南京医科大学第一附属医院胸外科江苏 南京 210029 
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中文摘要:
      目的:探索建立肺段切除术离体动物模型的可行性。方法:使用离体猪肺建立肺段切除术的动物模型。通过使用电刀分离6种不同的肺段,并分离完整的段间交界面。对不同肺段模型的漏气程度及建模时间进行综合评估与分析。结果:本研究明确了正常猪肺的肺段解剖结构。离体猪肺6种不同的肺段切除术模型均能顺利建立,对段间交界面的分辨、裁剪有较好的模拟效果。6种肺段离体模型漏气程度的差异均无统计学意义(P>0.05)。离体模型的建模时间比较,右肺顶叶a段的离体模型建模用时[(880±83)s]比其他5个肺段更短[右肺顶叶b段(1 531±79)s,左肺顶叶a段(1 384±75)s,左肺顶叶b段(1 207±56)s,左肺尾叶左a段(1 273±94)s,左肺尾叶右a段(1 179±108)s],建模时间的差异具有统计学意义(P<0.01),且右肺顶叶a段的样本剔除率(11.11%)低于平均值(26.24%)。结论:离体猪肺的右肺顶叶a段切除可作为较为理想的肺段切除术模型。
英文摘要:
      Objective:This work aimed to explore the feasibility of establishing ex vivo animal model of segmentectomy. Methods:The animal model of segmentectomy was established by ex vivo porcine lungs. Six different segments were separated by electrotome,and their intersegmental planes were completely removed in order to evaluate and analyze the degree of air leakage and modeling time between different segmentectomy. Results:We identified the normal anatomy of segments of pig lungs firstly,and all animal models of segmentectomy were successfully established,which could achieve a satisfying effect of the identification and separation of intersegmental plane. There was no significant difference in the level of air leakage among the six various segments(P > 0.05). The modeling time of the a segment of right cranial lobe(RS1a)segment[(880±83)s] was shorter than other segments[the b segment of right cranial lobe(RS1b):(1 531±79)s,the a segment of left cranial lobe(LS1a):(1 384±75)s,the b segment of left cranial lobe(LS1b):(1 207±56)s,the levo?a segment of left caudal lobe(LS2La):(1 273±94)s,the dextro?a segment of left caudal lobe(LS2Da):(1 179±108)s],and there were significant differences among them(P < 0.01),and RS1a also got a lower sample rejection rate(11.11%)compared to the average level(26.24%). Conclusion:The RS1a in ex vivo porcine lung can be utilized as an ideal model of segmentectomy for experiments.
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