文章摘要
王思远,张思慜,王焕强,徐济达,王建明,彭献镇.APC基因甲基化与上消化道肿瘤发病风险关联的Meta分析[J].南京医科大学学报,2020,(8):1235~1240
APC基因甲基化与上消化道肿瘤发病风险关联的Meta分析
Meta⁃analysis of the association between APC gene methylation and the risk of upper digestive tract tumor
投稿时间:2019-03-07  
DOI:10.7655/NYDXBNS20200830
中文关键词: APC  甲基化  上消化道肿瘤
英文关键词: APC  methylation  upper digestive tract tumor
基金项目:江苏省高等学校自然科学基金(17KJD 330002);南京医科大学科技发展基金(2017NJMUZD141);江苏省大学生创新创业训练计划项目(201713980005X)
作者单位
王思远 南京医科大学康达学院江苏 连云港 222000 
张思慜 南京医科大学公共卫生学院江苏 南京 211166 
王焕强 南京医科大学康达学院江苏 连云港 222000 
徐济达 南京医科大学康达学院江苏 连云港 222000 
王建明 南京医科大学公共卫生学院江苏 南京 211166 
彭献镇 南京医科大学康达学院江苏 连云港 222000 
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中文摘要:
      目的:探讨腺瘤性结肠息肉病(adenomatous polyposis coli,APC)基因甲基化与上消化道肿瘤发病风险的关联。方法:系统检索PubMed、Web of Science、Embase、CNKI等数据库,英文检索词为“APC”“methylation”“esophageal cancer/esophagus cancer”“gastric cancer/stomach cancer”,中文检索词为APC、甲基化、食管癌、胃癌,同时辅以人工检索参考文献。检索范围为2000年1月—2018年2月。应用固定效应模型或随机效应模型计算合并OR值及其95%CI。结果:入选研究共17项,病例组共1 201例,对照组共959例,数据表现为异质性。APC甲基化与上消化道肿瘤发病关联强度较高(OR=13.24,95%CI:6.42~27.33,P < 0.001)。同时APC甲基化与TNM分期也存在关联(OR=3.95,95%CI:1.46~10.66,P=0.007)。结论:APC基因甲基化与上消化道肿瘤发病关联程度明显,应用于上消化道肿瘤早期诊断价值较大。
英文摘要:
      Objective:To investigate the association between methylation of adenomatous polyposis coli(APC) gene and the risk of upper digestive tract tumor. Methods:Relevant articles were identified using PubMed,Web of Science,Embase and China National Knowledge Infrastructure(CNKI)database. We used the keywords “APC” and “methylation”,in conjunction with any of the following terms:“esophageal cancer”,“esophagus cancer”,“gastric cancer” or “stomach cancer”. References listed in the identified articles were further manually searched for additional studies. The search range was from January 2000 to February 2018. A random or fixed effect model was adopted to calculate pooled odd ratio with 95% confidence interval. Results:The current Meta?analysis included 17 studies with 1 201 cases and 959 controls. The significant heterogeneity was across studies. The pooled OR of APC methylation was 13.24(95% CI:6.42?27.33,P < 0.001)for upper digestive tract tumor. A significant association was found between the hypermethylation frequency and the increased TNM stages(pooled OR:3.95,95% CI:1.46?10.66,P=0.007). Conclusion:The present Meta?analysis provides evidence that APC promoter methylation is associated with an increased risk in upper digestive tract tumor. Our findings underscore the clinical relevance of aberrant methylation as a promising biomarker for upper digestive tract tumor.
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