文章摘要
高珂梦,李天女,丁重阳,赵 敏,唐立钧.肺小细胞癌18F⁃FDG PET代谢参数与相关代谢指标的关系[J].南京医科大学学报,2020,(12):1855~1859
肺小细胞癌18F⁃FDG PET代谢参数与相关代谢指标的关系
Correlation between metabolic parameters of 18F ⁃ FDG PET and related metabolic
投稿时间:2020-01-30  
DOI:10.7655/NYDXBNS20201223
中文关键词: 肺小细胞癌  18F⁃FDG PET  代谢参数  免疫标志物  预后
英文关键词: small cell lung cancer  18F⁃FDG PET  metabolic parameter  immunological markers  prognosis
基金项目:江苏省卫生计生委基金项目(Z201502)
作者单位
高珂梦 南京医科大学第一附属医院核医学科江苏 南京 210029 
李天女 南京医科大学第一附属医院核医学科江苏 南京 210029 
丁重阳 南京医科大学第一附属医院核医学科江苏 南京 210029 
赵 敏 南京医科大学第一附属医院核医学科江苏 南京 210029 
唐立钧 南京医科大学第一附属医院核医学科江苏 南京 210029 
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中文摘要:
      目的:探讨肺小细胞癌中18F?FDG PET/CT的各项代谢参数与神经内分泌标志物(Syn、CgA、CD56)、TTF?1、Ki?67表达的相关性及其预后价值。方法:回顾性分析南京医科大学第一附属医院2009年1月—2017年5月经病理证实的96例肺小细胞癌的免疫组化及18F?FDG PET/CT显像资料。结果:96例肺小细胞癌的原发灶最大标准摄取值(primary lesion maximum standardized uptake value,PSUVmax)、总病灶代谢体积(whole body lesion metabolic tumor volume,WBMTV)、总病灶糖酵解总量(whole body lesion glycolysis,WBTLG)分别为10.30(1.20~42.90)、108.44(0.41~710.40)cm3、585.73(1.30~10 668.50),TTF?1阴性组与阳性组的PSUVmax、WBMTV、WBTLG差异有统计学意义(Z=-3.063、-2.235、-2.538,P=0.002、0.025、0.011);PSUVmax值与Ki?67的表达呈正相关(r=0.620,P<0.05);单因素生存分析表明TTF?1、CD56、WBMTV、WBTLG与总生存期(overall survival,OS)相关(HR值:0.477、0.090、2.862、2.795,P均<0.05);多因素生存分析显示CD56及WBMTV是OS的独立预后因素(HR值:0.092、1.007,P均<0.05)。结论:肺小细胞癌中18F?FDG PET/CT显像的各项代谢参数与TTF?1、Ki?67的表达具有较好的相关性,而与神经内分泌标志物无明显相关性;CD56及WBMTV是OS的独立预后因素。
英文摘要:
      Objective:This study aims to investigate the correlation between the metabolic parameters of 18F?FDG PET/CT and the expression of neuroendocrine markers(Syn,CgA,CD56),TTF?1 and Ki?67,and the value of prognosis in small cell lung cancer(SCLC). Methods:The immunohistochemical data and 18F?FDG PET/CT data of 96 SCLC cases confirmed by pathology were retrospectively analyzed,the cases collected from January 2009 to May 2017 in the First Affiliated Hospital of Nanjing Medical University. Results:The median of primary lesion maximum standardized uptake value(PSUVmax),whole body lesion metabolic tumor volume(WBMTV)and whole body lesion glycolysis(WBTLG)in 96 SCLC patients were 10.30(1.20~42.90)、108.44(0.41~710.40)cm3、585.73(1.30~10 668.50);the values of PSUVmax,WBMTV and WBTLG had statistically significant differences between the negative and positive groups of TTF?1(Z=-3.063,-2.235,-2.538,P=0.002,0.025,0.011). The Spearman correlation analysis shows that there was a positive correlation between PSUVmax and Ki?67 expression(r=0.620,P < 0.001). Kaplan?Meier single factor analysis shows the expression of TTF?1 and CD56,WBMTV,WBTLG was significantly correlated with overall survival(HR:0.477,0.090,2.862,2.795,all P < 0.05). Multivariate survival analysis showed that CD56 and WBMTV were independent prognostic factors of overall survival(OS). Conclusion:The metabolic parameters of 18F?FDG PET/CT in SCLC had a good correlation with the expressions of TTF?1 and Ki?67,and no correlation with neuroendocrine markers. CD56 and WBMTV were the independent prognostic factors of OS.
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