肠道菌群与多囊卵巢综合征代谢异常关系研究进展
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无锡市卫计委重大项目(Z201807)


Study on the relationship between gut microbiota and abnormal metabolism of polycystic ovary syndrome
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    摘要:

    在育龄期女性中,多囊卵巢综合征(polycystic ovary syndrome,PCOS)的患病率已高达5%~10%,临床异质性大,发病机制尚不明确,大多数研究认为PCOS是一种多基因调控、多因素诱导、兼有糖脂代谢异常与类固醇激素代谢异常的疾病。近年来,越来越多的专家提出PCOS可能存在不同分型。肠道菌群作为近年来研究的热点,其与糖脂代谢紊乱、类固醇激素代谢紊乱存在关联,肠道菌群与多囊卵巢综合征发病机制的关系研究显得尤为重要。文章就肠道菌群与多囊卵巢综合征可能存在的关系进行综述。

    Abstract:

    At present,the prevalence of polycystic ovary syndrome(PCOS)is as high as 5%~10% among women of childbearing age. PCOS is characterized by high clinical heterogeneity and unclear pathogenesis. Most studies suggest that PCOS is a multi-gene-regulated,multi-factor-induced disease with abnormal metabolism of glucose,lipid and steroid hormone. In recent years,more and more experts have proposed that PCOS may have different types. Gut microbiota,as a hot research topic in recent years,is associated with disorders of glucose,lipid and steroid hormone metabolism. The relationship between gut microbiota and the pathogenesis of polycystic ovary syndrome is particularly important. This article reviews the possible relationship between gut microbiota and polycystic ovary syndrome.

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朱许萍,李艳瑜,许 岚.肠道菌群与多囊卵巢综合征代谢异常关系研究进展[J].南京医科大学学报(自然科学版),2020,(12):1885-1889

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  • 收稿日期:2020-03-13
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  • 在线发布日期: 2021-01-04
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