In recent years，the adverse reactions caused by irrational use of antibiotics，including allergy，drug resistance and hemolysis，have become a global problem threatening human health. Many countries strictly control the use of antibiotics to avoid unnecessary use of antibiotics，so as to reduce the spread of drug-resistant and drug-resistant problems in the world. At the same time，screening and identification of antibiotic susceptibility genes is the key to overcome the adverse reactions of antibiotics. This paper reviews the research progress of antibiotic use，adverse reactions（ADR），the relationship between antibiotic susceptibility and susceptibility genes，screening and identification of drug antibody susceptibility genes in recent years，which is of great significance for the clinical use and early warning of antibiotics，and the research of antibiotic antibody susceptibility genes in China.