Renal cell carcinoma is the most common malignancy in the kidney and its early symptoms are insignificant，with a significant proportion of patients already having metastases when they diagnosed. Renal cell carcinoma is not sensitive to radiotherapy and chemotherapy，which made sunitinib，a receptor tyrosine kinase inhibitor，to be the first-line treatment of metastatic renal cell carcinoma because of its anti-angiogenic effect. Despite the huge success of sunitinib in the treatment of kidney cancer，the emergence of resistance is almost inevitable as treatment progresses. In the human genome，the vast majority of transcribed sequences are non-coding transcripts. Among them，microRNA，long-non-coding RNA（lncRNA），and circular RNA are considered to play an important role in tumorigenesis and progression. In this review，we summarize the microRNAs and lncRNAs that linked to the renal cell carcinoma’s resistance to sunitinib.