Objective:To investigate the alterations of functional connectivity among Parkisnon’s disease(PD)patients with anxiety,and to explore its pathological mechanism. Methods:Totally 112 PD patients and 54 healthy controls underwent rs-fMRI scanning. According to the Hamilton anxiety scale(HAMA),112 PD patients were divided into 50 PD with anxiety group(PD-A)and 62 PD without anxiety(PD-NA). ANCOVA and post-hoc t test were performed to assess intergroup difference of voxel-mirrored homotopic connectivity(VMHC)value to obtain the abnormal brain regions. Bilateral amygdala were chosen as seeds to calculate functional connectivity with abnormal brain regions. Estimated a Pearson’s correlation coefficient between functional connectivity calculated above and HAMA scores. Results:VMHC value had significant differences among three groups,post hoc t test showed a decrease of VMHC value in bilateral inferior frontal gyri(IFG)triangular part and opercular part in PD-A group compared to the PD-NA group. Functional connectivity increased between the left amygdala and the left IFG. Furthermore,functional connectivity was positively correlated with HAMA scores. Conclusion:Abnormal brain functional activity exists in PD-A group,suggesting that anxiety in PD is associated with abormalities in IFG-amygdala loop network.