文章摘要
贾永锋,王建伟,刘 俊,张克忠,袁永胜,王 敏.帕金森病伴焦虑患者静息态功能磁共振脑功能连接改变的研究[J].南京医科大学学报,2021,(4):534~539
帕金森病伴焦虑患者静息态功能磁共振脑功能连接改变的研究
A resting⁃state functional magnetic resonance imaging study on functional connectivity alteration of Parkinson’s disease with anxiety
投稿时间:2020-11-12  
DOI:10.7655/NYDXBNS20210410
中文关键词: 帕金森病  焦虑  静息态功能磁共振成像  体素镜像同伦  功能连接  杏仁核
英文关键词: Parkinson’s disease  anxiety  resting⁃state functional magnetic resonance imaging  voxel⁃mirrored homotopic connecti⁃vity  functional connectivity  amygdala
基金项目:国家自然科学基金(81671258)
作者单位
贾永锋 南京医科大学第一附属医院放射科江苏 南京 210029 
王建伟 南京医科大学第一附属医院放射科江苏 南京 210029 
刘 俊 南京医科大学第一附属医院放射科江苏 南京 210029 
张克忠 南京医科大学第一附属医院神经内科江苏 南京 210029 
袁永胜 南京医科大学第一附属医院神经内科江苏 南京 210029 
王 敏 南京医科大学第一附属医院放射科江苏 南京 210029 
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中文摘要:
      目的:观察帕金森病(Parkinson’s disease,PD)伴焦虑患者静息态功能连接改变,并探索PD伴发焦虑的神经病理机制。方法:收集112例PD患者以及54例健康对照者的静息态功能磁共振成像(rs?fMRI)数据,根据汉密尔顿焦虑量表(HAMA)将PD组分为PD伴焦虑(PD?A组)50例和PD不伴焦虑(PD?NA组)62例。通过协方差分析(ANCOVA)和post?hoc t检验进行体素镜像同伦连接(voxel?mirrored homotopic connectivity,VMHC)值的组间统计学比较得到PD?A组与PD?NA组的差异脑区。选取双侧杏仁核为功能连接种子点,计算双侧杏仁核与差异脑区功能连接结果,并分析功能连接值与HAMA评分的相关性。结果:PD?A组、PD?NA组和健康对照组之间的VMHC值有显著性差异,组间post?hoc t检验显示,PD?A与PD?NA相比,双侧额下回(inerior frontal gyrus,IFG)三角部及岛盖部VMHC值减低。种子点功能连接显示左侧杏仁核与左侧额下回的功能连接增强,且功能连接值与HAMA评分呈正相关。结论:PD?A患者存在异常的脑功能活动,双侧额下回的异常VMHC改变以及左侧杏仁核与左侧额下回的功能连接异常,提示额下回?杏仁核相关网络环路可能参与了焦虑的病理发生过程。
英文摘要:
      Objective:To investigate the alterations of functional connectivity among Parkisnon’s disease(PD)patients with anxiety,and to explore its pathological mechanism. Methods:Totally 112 PD patients and 54 healthy controls underwent rs?fMRI scanning. According to the Hamilton anxiety scale(HAMA),112 PD patients were divided into 50 PD with anxiety group(PD?A)and 62 PD without anxiety(PD?NA). ANCOVA and post?hoc t test were performed to assess intergroup difference of voxel?mirrored homotopic connectivity(VMHC)value to obtain the abnormal brain regions. Bilateral amygdala were chosen as seeds to calculate functional connectivity with abnormal brain regions. Estimated a Pearson’s correlation coefficient between functional connectivity calculated above and HAMA scores. Results:VMHC value had significant differences among three groups,post hoc t test showed a decrease of VMHC value in bilateral inferior frontal gyri(IFG)triangular part and opercular part in PD?A group compared to the PD?NA group. Functional connectivity increased between the left amygdala and the left IFG. Furthermore,functional connectivity was positively correlated with HAMA scores. Conclusion:Abnormal brain functional activity exists in PD?A group,suggesting that anxiety in PD is associated with abormalities in IFG?amygdala loop network.
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