Cardiovascular disease is a serious threat to human health，and it is also the main cause of death in the world. The traditional two dimensional（2D）cell model and animal model have their own limitations，which cannot be fully applied to the mechanism and treatment of cardiovascular disease. Organoid is a kind of three dimensional（3D）culture in vitro and simulates the cell structure of organ in vivo，which can more accurately retain the biological characteristics and functions of cells in vivo. It is a new direction and idea for the research of cardiovascular disease. Now，many studies have reported the construction methods of cardiac organs and their applications in drug experiments，disease models，regenerative medicine in treatment and so on. In this review，it was summarized the construction methods of cardiac organs and their clinical applications，and also put forward their development prospects and limitations.