文章摘要
Ashish Kumar Sharma,Kunal Kishore,Divya Sharma,B.P Srinivasan,Shyam Sunder Agarwal,Ashok Sharma,Santosh Kumar Singh,Samir Gaur,Vijay Singh Jatav.[J].南京医科大学学报,2011,(4):280~286
Cardioprotective activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats
  
DOI:10.7655
中文关键词: 
英文关键词: Tinospora cordifolia, arrhythmia, cardioprotection
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作者单位
Ashish Kumar Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
Kunal Kishore Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
Divya Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
B.P Srinivasan Delhi Institute of Pharmaceutical Sciences & Research, Department of Pharmacology, Pushpvihar, Sector-III. New Delhi 110017, India. 
Shyam Sunder Agarwal Delhi Institute of Pharmaceutical Sciences & Research, Department of Pharmacology, Pushpvihar, Sector-III. New Delhi 110017, India. 
Ashok Sharma Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
Santosh Kumar Singh Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
Samir Gaur Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
Vijay Singh Jatav Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan)302025, India 
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中文摘要:
      
英文摘要:
      The present study investigated the antiarrhythmic activity of alcoholic extract of Tinospora cordifolia (T. cor-difolia) in CaCl2 induced arrhythmia. CaCl2 (25 mg/kg) was administered by intravenous infusion (iv) to produce arrhythmia in rats. The animals were then treated with T. cordifolia extract (150, 250, and 450 mg/kg) and vera-pamil (5 mg/kg,iv). Lead II electrocardiogram was monitored. Plasma calcium, sodium and potassium levels were measured. In CaCl2 induced arrhythmia, heart rate was decreased by 41.10%, T. cordifolia at 150, 300, and 450 mg/kg decreased the heart rate by 26.30%, 29.16%, and 38.29%, respectively, and verapamil reduced the heart rate by 9.70% compared to the normal group. The PQRST waves were normalized and atrial and ventricular fi-brillation was controlled in rats treated with verapamil and T. cordifolia. CaCl2 increased calcium and sodium lev-els and decreased potassium levels in blood. T. cordifolia dose-dependently decreased calcium and sodium levels and increased potassium levels. Hence, T. cordifolia can be used in antiarrhythmic clinical settings and beneficial in atrial and ventricular fibrillation and flutter and may be indicated in ventricular tachyarrhythmia.
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