文章摘要
Xin Wang,Jianying Zhang,Yi Liu,Yingdong Zhang.[J].南京医科大学学报,2011,(4):287~291
Relationship between nerve injury-induced protein gene 2 polymorphism and stroke in Chinese Han population
  
DOI:10.7655
中文关键词: 
英文关键词: nerve injury-induced protein 2 (NINJ2), single nucleotide polymorphism (SNP), stroke, cell adhesion molecule
基金项目:
作者单位
Xin Wang Department of Neurology, Medical School of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Jianying Zhang Department of Neurology, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China 
Yi Liu Department of Neurology, Medical School of Nanjing Medical University, Nanjing, Jiangsu 210029, China 
Yingdong Zhang Department of Neurology, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China 
摘要点击次数: 815
全文下载次数: 58
中文摘要:
      
英文摘要:
      The aim of present study was to investigate the relationship between nerve injury-induced protein 2 (NINJ2) gene polymorphism and stroke in Chinese Han population. Fifty-two patients with large-artery atherosclerosis (LAA) infarction, 85 patients with small-artery occlusion lacunar (SAO) infarction, 50 patients with intracerebral hemorrhage (ICH) and 66 controls were included. Genotypes and alleles frequencies of the two single nucleotide polymorphisms (SNPs) of NINJ2 among different groups were analyzed and compared. In regard to rs12425791, the frequencies of the AG and AA+AG genotypes of the LAA and SAO groups were significantly higher than those in the control group; the frequency of the A allele of the SAO group was significantly higher than that of the con-trol group. In regard to rs11833579, there were not any significant differences between the case and the control groups. The SNP rs12425791 is significantly associated with ischemic stroke, and the A allele increases the sus-ceptibility to stroke. The SNP rs11833579 is not significantly associated with stroke.
查看全文   查看/发表评论  下载PDF阅读器
关闭