文章摘要
程虹,丁新生,王琨,张雪玲,王颖,姚娟,邓晓萱.脑脊液中β-淀粉样蛋白检测与阿尔茨海默病的早期诊断[J].南京医科大学学报,2003,17(3):
脑脊液中β-淀粉样蛋白检测与阿尔茨海默病的早期诊断
The Value of CSF Level of β-amyloid Protein in the Diagnosis of Alzheimer's Disease
  
DOI:10.7655
中文关键词: 阿尔茨海默病、脑脊液、β-淀粉样蛋白
英文关键词: Alzheimer's disease  cerebrospinal fluid  β-amyloid protein
基金项目:
程虹  丁新生  王琨  张雪玲  王颖  姚娟  邓晓萱
南京医科大学第一附属医院神经内科,南京,210029,中国;南京医科大学第一附属医院神经内科,南京,210029,中国;南京医科大学第一附属医院神经内科,南京,210029,中国;南京医科大学第一附属医院神经内科,南京,210029,中国;南京医科大学第一附属医院神经内科,南京,210029,中国;南京医科大学第一附属医院神经内科,南京,210029,中国;南京医科大学第一附属医院神经内科,南京,210029,中国;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China;
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中文摘要:
      目的:检测β-淀粉样蛋白(β-amyloid protein,Aβ)两种主要成分Aβi-40和Aβ1-42在阿尔茨海默病(Alzheier's Disease,AD)脑脊液中的变化,并探讨其对AD的诊断价值.方法:采用敏感的双抗体夹心酶联免疫吸附法(ELISA),检测54例AD患者脑脊液中Aβ的浓度,并与30例正常对照者(normal controls,NC)脑脊液中的相应成分进行对比.结果:①AD患者脑脊液中Aβ1-42浓度低于正常对照组,而Aβ1-40/Aβ1-42比值高于对照组;②以脑脊液中Aβ比值及Aβ1-42浓度检测诊断AD的敏感性分别为54.51%、90.00%,特异性为84.25%、84.38%.结论:临床上同时检测脑脊液中Aβ1-42浓度及Aβ比值可作为早期诊断AD的辅助指标,具有一定的临床应用价值.
英文摘要:
      Objective:To evaluate the diagnostic potential of cerebrospinal fluid ( CSF) levels of β-amyloid protein (Aβ) as biochemical marker for senile dementia in clinical practice. Methods: Sensitive enzyme-linked immunosorbent assay ( ELISA) was performed in our laboratory to detect the CSF levels of Aβ1-40, Aβ1-42 in 54 patients with Alzheimer's disease (AD), and 30 normal controls (NC). Results: The cut off value of Aβ ratio and Aβ1-42 concentration in NC group provided 54. 51%, 90. 00% sensitivity and 81. 25%, 84. 38% specificity respectively in diagnosis of AD. Conclusion: AD group bad a significant decreased level of Aβ1-42 and an increased level of Aβ ratio, compared with NC group.
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