文章摘要
Mei Zhang,Chao Liu,Cuiping Liu,Youwen Qin,Zhaosun Zhen.[J].南京医科大学学报,2005,19(2):
Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival
  
DOI:10.7655
中文关键词: 
英文关键词: allogeneic transplantation  immunoisolation  microencapsulation  islets  rat
基金项目:
Mei Zhang  Chao Liu  Cuiping Liu  Youwen Qin  Zhaosun Zhen
Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
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中文摘要:
      
英文摘要:
      Objective: To evaluate the immunoisolating effects of barium-alginate microencapsulation on islets allograft survival. Methods: The nonmicroencapsulated and microencapsulated islets were transplanted under the kidney capsule or intraperitoneally into Wistar rat with STZ-induced diabetes. The blood glucose and insulin secretion of grafts were observed. Graft function was tested by oral rats was associated with normal glucose and insulin profiles in response to OGTT. Conclusion: Microencapsulation with barium-alginate membrane can prolong islet survival and protect islets against allorejection.
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