文章摘要
Xiaobing Lei,Shengshun Tan,Weihui Zeng,Junmin Wang,Panjian Zhang,Yuan Yuan.[J].南京医科大学学报,2005,19(2):
Analysis of T-lymphocyte subtypes of the peripheral blood and skin delayed-type hypersensitivity in patients with hyper-IgE syndrome
  
DOI:10.7655
中文关键词: 
英文关键词: Hyper-IgE Syndrome  T-lymphocyte subtypes  delayed-type hypersensitivity
基金项目:
Xiaobing Lei  Shengshun Tan  Weihui Zeng  Junmin Wang  Panjian Zhang  Yuan Yuan
Department of Dermatology, the Second Hospital of Xi' an Jiaotong University, Xi' an 710004, China;Department of Dermatology, the Second Hospital of Xi' an Jiaotong University, Xi' an 710004, China;Department of Dermatology, the Second Hospital of Xi' an Jiaotong University, Xi' an 710004, China;Department of Dermatology, the Second Hospital of Xi' an Jiaotong University, Xi' an 710004, China;Department of Dermatology, the Second Hospital of Xi' an Jiaotong University, Xi' an 710004, China;Department of Dermatology, the Second Hospital of Xi' an Jiaotong University, Xi' an 710004, China
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中文摘要:
      
英文摘要:
      Objective: To study the function of cellular immunity in patients with hyper-IgE syndrome (HIE). Methods:T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-type hypersensitivity (DTH) response to two recall antigens, tetanus toxoid (TT) and purified protein derivative(PPD), were measured in five patients with HIE and 15 healthy controls, respectively. Results: The CD4+ cell counts in HIE group were significantly lower than those in control group ( P < 0.01). In contrast, CD8 + cells were significantly higher than those in the control ( P < 0.01). The induration sizes of DTH response to two recall antigens were smaller in HIE group than those in the control group ( P < 0.01 ). Conclusion: There was an immunologic dysfunction of T lymphocytes in the patients with HIE.
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