文章摘要
Yonghui Zhao,Changcong Cui,Yanni Wang,Jiaqing Zhu.[J].南京医科大学学报,2005,19(3):
Effect of the platelet membrane GP Ⅰ a gene polymorphism in the pathogenesis of unstable angina pectoris
  
DOI:10.7655
中文关键词: 
英文关键词: platelet  glycoprotein  polymorphism  angina pectoris
基金项目:
Yonghui Zhao  Changcong Cui  Yanni Wang  Jiaqing Zhu
Cardiovascular Disease Department, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China;Cardiovascular Disease Department, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China;Cardiovascular Disease Department, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China;Cardiovascular Disease Department, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China
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中文摘要:
      
英文摘要:
      Objective: To investigate the effect of platelet membrane glycoprotein(GP) Ⅰ a gene polymorphism in the pathogenesis of unstable angina pectoris (UAP) in Chinese people. Methods: Collagen type Ⅰ -induced platelet aggregation was measured in 33healthy subjects in vitro. Plasma level of α-granule membrane protein (GMP-140) was measured in both the above 33 healthy subjects during fasting and 35 patients with recent onset effort anina during rest onset within 24 h after hospitalization. Furthermore, the platelet membrane GP Ⅰ a gene 807C/T polymorphism was checked in all subjects with polymerase chain reaction-sequence specific primers(PCR-SSP)technique. Results: The lag time before 30% platelet aggregation was significantly longer in healthy subjects with CC genotype than with TC genotype ( P <0.01). However, there was no significant difference in the maximal platelet aggregation between healthy subjects with the above two genotypes. Plasma level of GMP-140 was significantly higher in TC genotypic patients with recent onset effort angina than in CC genotypic patients with the same type of UAP( P < 0.05) and healthy subjects ( P < 0.01), furthermore, there was also significant difference between the latter two groups( P < 0.05). Conclusion: The rapid initiation of collagen-induced platelet aggregation may be associated with platelet membrane GP Ⅰ a T807 allele, which may play an important role in the pathogenesis of UAP.
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