文章摘要
Yun Yang,Wanggang Zhang,Yichao Qiao,yinxia Chen,Xingmei CAO.[J].南京医科大学学报,2005,19(3):
Expressions of IL-10 on leukemic cells in acute leukemic patients and its significance
  
DOI:10.7655
中文关键词: 
英文关键词: acute leukemia  leukemic cells  IL-10
基金项目:
Yun Yang  Wanggang Zhang  Yichao Qiao  yinxia Chen  Xingmei CAO
Department of Hemotology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China;Department of Hemotology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China;Department of Hemotology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China;Department of Hemotology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China;Department of Hemotology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China
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中文摘要:
      
英文摘要:
      Objective: To explore the expressions of IL-10 on leukemic cells in acute leukemia patients and its significance.Methods: The expressions of IL-10 on leukemic cells in thirty patients was measured by indirect immunofluorescence technique. Results:Observed yellow-green bright fluorescence on leukemic cells membrane, the positive rate of cells was 10-80%, there were 18 patients expressing IL-10 (18/30, 60%) positively, among them 11 with ANLL (11/19, 58%) and 7 with ALL (7/11, 64%) respectively while that of peripheral mononucleate cells in control group was 13 %. Compared with that in the control group, there was a significant increase of positive rate in ANLL and ALL but with no significant difference between ANLL and ALL. Conclusion: IL-10 secreted by leukemic cells, contributed to the immunosuppressive state at the tumor site. This is probably one of the important mechanisms of acute leukemic escape.
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