文章摘要
Puwei Yuan,Xijing He,Dong Wang,HaoPeng Li,Binshang Lan,Huiru Lu.[J].南京医科大学学报,2005,19(3):
Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head
  
DOI:10.7655
中文关键词: 
英文关键词: femur head necrosis  tumor necrosis factor-α  Pathological processes
基金项目:
Puwei Yuan  Xijing He  Dong Wang  HaoPeng Li  Binshang Lan  Huiru Lu
Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China;Department of Orthopedics, Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China
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中文摘要:
      
英文摘要:
      Objective: To explore the effect of tumor necrosis factor-α(TNF-α)on the occurrence of steroid-induced avascular necrosis of femoral head(SANFH). Methods: Twenty-four rabbits were firstly divided into void group ( n = 12) and model group ( n =two groups were killed respectively to observe whether the model was successful. The level of TNF-α in serum of the residual rabbits of the two groups was examined in Radioimmunoassay method. Results: The level of TNF-α in model group is significantly higher than that in void group( P <0.001) under the premise of the model of SANFH success by histological observation. Conclusion: The rise of level of TNF-α may be one of the most important factors in the occurrence of SANFH.
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