文章摘要
Yuanyuan Zhao,Yuhui Ni,Xirong Guo,Haixia Gong,Xia Chi,Ronghua Chen.[J].南京医科大学学报,2006,20(1):
Adipose tissue resistin gene expression in DIO and DR rats
  
DOI:10.7655
中文关键词: 
英文关键词: obesity  DIO  DR  resistin  insulin resistance
基金项目:
Yuanyuan Zhao  Yuhui Ni  Xirong Guo  Haixia Gong  Xia Chi  Ronghua Chen
Nanjing Red Cross Blood Center, Nanjing 210003;Department of Pediatrics, Center of Human Functional Genomics of Nanjing Medical University, Nanjing 210029, China;Department of Pediatrics, Center of Human Functional Genomics of Nanjing Medical University, Nanjing 210029, China;Department of Pediatrics, Center of Human Functional Genomics of Nanjing Medical University, Nanjing 210029, China;Department of Pediatrics, Center of Human Functional Genomics of Nanjing Medical University, Nanjing 210029, China;Department of Pediatrics, Center of Human Functional Genomics of Nanjing Medical University, Nanjing 210029, China
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英文摘要:
      Objective: To investigate the expression of resistin gene in diet-induced obesity (DIO) and diet resistance (DR)rats. Methods: DIO and DR models were prepared with male SD rats after 6 weeks feeding by a diet of relatively high fat, sucrose, and caloric content (HE diet). Body-weight, fat mass, and the concentration of serum insulin were measured, and the expression of resistin and Peroxisome proliferator-activated receptory-γ(PPAR-γ) gene in whit adipose tissue (WAT) was also detected by RT-PCR. Results: ①Body weight, fat mass and the concentration of serum insulin were significantly increased in DIO rats and decreased in DR rats. ② The expression of resistin and PPARγ gene was upregulated in DIO group and supressed in DR group, but the expression of resistin was not detectable in all samples within three groups. Conclusion: Resistin may serve as a link between obesity and insulin resistance, but the individual difference is enormous.
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