文章摘要
Qiang Wang,Kunzheng Wang,Xiaoqian Dang.[J].南京医科大学学报,2006,20(2):
The effects of soybean isoflavaones on the mRNA expression of OPG,ODF and M-CSF in bone tissue of ovariectomized rat
  
DOI:10.7655
中文关键词: 
英文关键词: soybean isoflavaones  osteoporosis  cytokine  bone density
基金项目:
Qiang Wang  Kunzheng Wang  Xiaoqian Dang
Department of Orthopaedics Surgery, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China;Department of Orthopaedics Surgery, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China;Department of Orthopaedics Surgery, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China
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英文摘要:
      Objective: To observe the effects of the soybean isoflavaones on the mRNA expression of osteoprotegerin(OPG),osteoclast differentiation factor(ODF) and macrophage colony stimulating factor(M-CSF) in bone tissue of ovariectomized rat, and to investigate the possible pathway to prevent and treat postmenopausal osteoporosis using soybean isoflavaones. Methods: Thirty healthy adult SD rats were randomly divided into 3 groups: sham-operated group, ovariectomized group and soybean isoflavaones treated group. All rats were ovariectomized except those in sham-operated group. The bone density of the 3-6th lumbar vertebrae was detected after 12 weeks.Total RNA was extracted from femur bone and the mRNA expression of OPG, ODF and M-CSF was examined by real time PCR.Results: Soybean isoflavaones increased the bone density of the lumbar vertebrae in ovariectomized rat and up-regulated the expression of OPG, whereas down-regulated the expression of M-CSF and the ratio of ODF to OPG. Conclusion: The effects of soybean isoflavaones on postmenopausal osteoporosis are tightly correlated with OPG, M-CSF and the ratio of ODF to OPG.
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