文章摘要
Junbo Yu,Zekuan Xu,Shuguang Han,Yi Miao.[J].南京医科大学学报,2006,20(5):263~265
Studies of CTLA4Ig in acute rejection of pancreas transplantation in rats
  
DOI:10.7655
中文关键词: 
英文关键词: pancreas transplantation%rejection%CTLA4Ig%rats
基金项目:the "135" Foundation of Jiangsu Province(2003-19)
Junbo Yu  Zekuan Xu  Shuguang Han  Yi Miao
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英文摘要:
      Objective: To investigate the protective effect of CTLA4Ig in rejection of pancreaticoduodenal transplantation model of rat. Methods: Pancreaticoduodenal transplantion models were established from the donor F344 rats to the Lewis recipients. The models were divided into 2 groups: Group A and B with 12 rats in each group.2 days after transplantation, reciepients in group A were treated with i.p. injection of sailine, and those in group B CTLA4I were injected(200 μg). On day 1,4,7,10after transplantation, the grafts were harvested for histopathological examination. On day 4 after transplantation, the CD4+CD25+Tcells in the grafts were detected by Flow Cytometry. Results: Compared with group A: the degree of the rejection of grafts in group B was lower. The number of CD4+CD25+ T cells of graft was (7.91±1.26)﹪ in group A and (13.81±1.71)﹪ in group B, which had significant difference(P<0.01). Conclusion: CTLA4Ig could inhibit T cell costimulatory pathway, prevent acute rejection, which might be mediated by increasing the number of CD4+CD25+ regulatory T cells.
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