文章摘要
Juqing Jin,Yuhai Tang,Langchong He,Hong Yao,Yuanyuan Sun.[J].南京医科大学学报,2006,20(5):266~270
Determination of ribavirin by flow injection chemiluminescence
  
DOI:10.7655
中文关键词: 
英文关键词: flow injection analysis%chemiluminescence%ribavirin
基金项目:
Juqing Jin  Yuhai Tang  Langchong He  Hong Yao  Yuanyuan Sun
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中文摘要:
      
英文摘要:
      Objective: To establish a rapid and precise continuous flow-injection chemiluminescence (CL) method to determine ribavirin. Methods: The ribavirin could restrain strongly CL reaction of luminol in sodium hydroxide (NaOH) solution with potassium chlorate(KClO3). The different experimental parameters affecting the CL intensity were studied carefully. Results:Under optimum conditions(The concentrations of luminol,KClO3, and NaOH were at 0.1 mmol/L,0.5 μmol/L,and 0.2 mol/L, respectively), the linear range of the working curves was 0.01-7.00 μg/ml with a detection limit of 0.004 μg/ml. Conclusion: The method is simple, rapid and sensitive, and successfully applied to the determination of ribavirin in pharmaceutical preparations and biological fluids.
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