文章摘要
Tiebing Zhu,Jun Wang,Leming Fan,Yong Li,Zhijian Yang,Kejiang CAO,Jun Huang.[J].南京医科大学学报,2006,20(5):271~274
The V264M polymorphism of tissue factor pathway inhibitor gene in patients with acute coronary syndrome
  
DOI:10.7655
中文关键词: 
英文关键词: acute coronary syndrome%TFPI%polymorphism%plasma
基金项目:Education Department of Jiangsu Province(01KJB32006)
Tiebing Zhu  Jun Wang  Leming Fan  Yong Li  Zhijian Yang  Kejiang CAO  Jun Huang
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中文摘要:
      
英文摘要:
      Objective: To investigate V264M polymorphism of tissue factor pathway inhibitor (TFPI) in patients with acute coronary syndrome (ACS) in Chinese. Methods: The genotypes of V264M were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (PCR-RFLP) in 136 patients with ACS and 106 healthy controls with their plasmal f-TFPI tested by enzyme linked immunosorbent assay (ELISA). Results: Two genotypes were found in V264M: GG and GA. The distribution frequencies of alleles and genotypes were in accordance with those predicted by Hardy Weinberg equilibrium in the present study (χ2 = 0.437, P>0.05). Plasma f-TFPI level was lower in A allele bearer than that in non-A allele carriers and higher in ACS than control subjects (P<0.05). No relationship was found between ACS and V264M polymorphism (P>0.05).Conclusion: The V264M polymorphism may have an impact on the plasma level of free TFPI(f-TFPI), but it has no relationship with ACS.
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