文章摘要
Liansheng Wang, Zhijian Yang,Wei Wang,Dongchao Ma,Shunlin Xu,Yuqing Zhang,Fang Zhou,Bo Chen,Kejiang Cao,Jun Huang.[J].南京医科大学学报,2007,(2):72~76
Comparative study of effects of bone marrow cell vs. Ad5-HGF administration via non-infarct-related artery injection in myocardial infarction in swine
投稿时间:2006-10-10  
DOI:10.7655
中文关键词: 
英文关键词: Bone marrow-derived mesenchymal stem cells  hepatocyte growth factor  angiogenesis
基金项目:
作者单位
Liansheng Wang Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Zhijian Yang Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Wei Wang Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Dongchao Ma Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Shunlin Xu Department of Cardiology, the Third Hospital of Beijing University, Beijing 100083, China 
Yuqing Zhang Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Fang Zhou Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Bo Chen Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Kejiang Cao Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
Jun Huang Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 
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中文摘要:
      
英文摘要:
      Objective: To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells(BM-MSCs) or adenovirus5-hepatocyte growth factor(Ad5-HGF) via non-infarct-related artery injection in swine myocardial infarction models. Methods:BM-MSCs were obtained from swine bone marrow and expanded in vitro to a purity of >50%. A myocardial infarction(MI) was created by ligating the distal left anterior descending artery in swine. Either BM-MSCs(5 × 106/ml) or Ad5-HGF(4 × 109 pfu) were transfused via the right coronary artery(non-infarcted artery) four weeks after MI. Gate-controled cardiac perfusion imaging was performed at the end of four and seven weeks after LAD ligation, to evaluate heart function and cardiac perfusion. Morphologic and histologic characteristics of the hearts were also studied. Results:(1)The gate-controlled cardiac perfusion imaging showed that the improvement in LVEF was greater in both treatment groups than in control group at the 4th weeks. (2)In both treatment groups, capillary density was significantly higher than that of control group(P < 0.05). Conclusion:BM-MSCs or Ad5-HGF transplantation via non-infarcted artery administration can stimulate angiogenesis and improve heart function, but there was no difference in therapeutic efficacy between BM-MSCs and Ad5-HGF.
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