文章摘要
Xiaoxu Liu,Huafeng Kang,Xijing Wang,Zhijun Dai, Fengjie Xue,Xinghuan Xue.[J].南京医科大学学报,2007,(2):108~111
The Chemopreventive Effect of Tamoxifen Combined with Celecoxib on DMBA chemically-Induced Breast Cancer
投稿时间:2006-10-16  
DOI:10.7655
中文关键词: 
英文关键词: breast neoplasm  chemoprevention  tamoxifen  cyclooxygenase-2
基金项目:
作者单位
Xiaoxu Liu Department of Oncological Surgery, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an710004, China 
Huafeng Kang  
Xijing Wang  
Zhijun Dai  
Fengjie Xue  
Xinghuan Xue  
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中文摘要:
      
英文摘要:
       Objective: To investigate the chemopreventive effect of tamoxifen combined with a COX-2 selective inhibitor, celecoxib, on breast cancer in rats chemically induced by 7,12-dimethylben(a)anthracene (DMBA). Methods:DMBA was irrigated into the stomaches of SD female rats to build breast cancer model. A total of 120 rats were divided into four groups: control group, tamoxifen group, celecoxib group and combined group. The incidence rate, latent period, number and volume of breast cancer were detected and analyzed. Results:The tumor incidence rate of tamoxifen group (48.15%, 13/27) and celecoxib group (50.00%, 14/28) were lower than that of control group (85.71%, 24/28), but higher than that of combined group (21.43%, 6/28). The tumor’s latent period of tamoxifen group (97.54±1.85 d) and celecoxib group (96.79±2.89 d) were longer than that of control group (89.50±5.99 d), but shorter than that of combined group (103.67±3.39 d). The average tumor number of tamoxifen group (1.77±0.73) and celecoxib group (1.71±0.61) were less than that of control group (3.50±1.62), but more than that of combined group (1.17±0.42). The average tumor volume of tamoxifen group (1.78±0.71 cm3) and celecoxib group (2.05±1.04 cm3) were smaller than that of control group (6.42±3.96 cm3), but bigger than that of combined group (0.71±0.96 cm3) (P < 0.05 respectively). Conclusion:Celecoxib and tamoxifen are effective drugs in preventing the occurrence of rat breast cancer chemically induced by DMBA. Furthermore, combination of them has better chemopreventive effect.
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