文章摘要
Xiang Gao, Kun Liu, Jinping Liu,Yanfu Wang,Changwei Zhang,Zhijian Chen,Qiutang Zeng,Yuhua Liao.[J].南京医科大学学报,2008,28(1):1~4
Effects of sodium ferulate on the ultrarapid delayed rectifier K+
投稿时间:2007-07-25  
DOI:10.7655
中文关键词: 
英文关键词: sodium ferulate  ultrarapid delayed rectifier K+ current  patch clamp
基金项目:
作者单位
Xiang Gao Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Kun Liu Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Jinping Liu Department of Cardiac surgery, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Yanfu Wang Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Changwei Zhang Department of Cardiac surgery, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Zhijian Chen Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Qiutang Zeng Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
Yuhua Liao Department of Cardiology, Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei province, 430022, China 
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中文摘要:
      
英文摘要:
       Objective:To study the effects of sodium ferulate on the ultrarapid delayed rectifier K+ current(IKur) in human atrial myocytes. Methods:Human atrial myocytes were isolated by enzyme dispersion method. IKur in human atrial myocytes were recorded by using the whole cell patch clamp. The changes of IKur were compared in the absence and the presence of sodium ferulate. Results:There was no effect of 0.4 g/L sodium ferulate on I-V relation of IKur. However, 0.4 g/L sodium ferulate inhibited IKur to some degrees at each test pulse. The current densities of IKur at +60 mV decreased from 4.997±0.35 PA/PF to 3.331±0.26 PA/PF(n = 6, P < 0.05). The inhibitory effect was concentration-dependent. IC50 was(0.41±0.03)g/L and the Hill coefficient was 0.95±0.05. Conclusion:Sodium ferulate as a potassium channel blocker can inhibit IKur in human atrial myocytes effectively.
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