文章摘要
Hongxia Xing,Hai Peng,Xuebing Cao,Shenggang Sun.[J].南京医科大学学报,2008,28(1):12~17
?Effect and mechanism of homocysteine on Parkinson’s disease induced by 6-OHDA
投稿时间:2007-09-10  
DOI:10.7655
中文关键词: 
英文关键词: Parkinson’s disease  6-hydroxydopamine  homocysteine  tyrosine hydroxylase
基金项目:
作者单位
Hongxia Xing Department of Neurology, The First Hospital of Xinxiang Medical College, Xinxiang 453100, Henan Province,China 
Hai Peng Department of Neurology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province,China 
Xuebing Cao Department of Neurology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province,China 
Shenggang Sun Department of Neurology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province,China 
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中文摘要:
      
英文摘要:
      Objective: To study the effects and mechanism of homocysteine(Hcy) on Parkinson’s disease(PD) induced by 6-hydroxydopamine(6-OHDA) in vivo. Methods:Forty rats were divided into 4 groups. 6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD, 2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra(SN). We used behavioral testing, Immolunohistochemical techniques, biochemistry techniques to detect the injury of SN. Results:The rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls(P < 0.05). Also the numbers of tyrosine hydroxylase(TH)-stained neurons were decreased, and dendrites were fragmented and truncated. Free radicals were increased and antioxidant enzymes decreased. Conclusion:Focal infusion of Hcy into the SN increased the vulnerability of the dopaminergic neurons to 6-OHDA-induced degeneration, it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.
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