文章摘要
Zhizhong Zhang,Guangbo Fu,Meilin Wang, Na Tong,Shizhi Wang,Zhengdong Zhang.[J].南京医科大学学报,2008,28(5):279~285
P53 codon 72 polymorphism and ovarian cancer risk: a meta-analysis
投稿时间:2008-07-19  
DOI:10.7655
中文关键词: 
英文关键词: p53  ovarian cancer  genetic susceptibility  meta-analysis
基金项目:
作者单位
Zhizhong Zhang Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Guangbo Fu Department of Urology, the Huai-An First Affiliated Hospital of Nanjing Medical University, Huai-An 223300 , Jiangsu Province, China 
Meilin Wang Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Na Tong Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Shizhi Wang Department of Molecular and Genetic Toxicology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
Zhengdong Zhang Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China 
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中文摘要:
      
英文摘要:
      Objective: p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer. Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting results. We performed this meta-analysis from eligible studies to evaluate this purported relationship. Methods: This meta-analysis was performed from 9 case-control studies, including 825 ovarian cases and 1073 controls. The fixed and random effect models were used to estimate the odds ratios(ORs) for various contrasts of this polymorphism. Results: The combined results based on all studies showed that a significantly decreased risk was associated with the variant Pro/Pro genotype, compared with Arg/Pro+Arg/Arg genotypes(OR, 0.70; 95%CI, 0.51~0.95). When stratifying the studies by ethnicity, we found that individuals with the variant genotype Pro/Pro had a significantly decreased risk of ovarian cancer compared with Arg/Arg genotype(OR, 0.43; 95%CI, 0.20~0.89) and Arg/Pro+Arg/Arg genotypes(OR, 0.61; 95%CI, 0.37~0.99) among Africans. Conclusion: This meta-analysis suggests that the p53 codon 72 polymorphism may contribute to genetic susceptibility to ovarian cancer. More studies based on larger sample size should be performed to confirm the findings.
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