文章摘要
Chunfang Li,Wenli Gou,Yunping Sun,Huang Pu.[J].南京医科大学学报,2008,28(5):290~294
Effect of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rats offspring with fetal growth restriction
投稿时间:2008-05-05  
DOI:10.7655
中文关键词: 
英文关键词: FGR  learning and memory  behavior training  NR2B  GluR1
基金项目:
作者单位
Chunfang Li Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China 
Wenli Gou  
Yunping Sun  
Huang Pu  
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中文摘要:
      
英文摘要:
       Objective: To study effects of behavior training on learning, memory and the expression of NR2B, GluR1 in hippocampus of rat’s offspring with fetal growth restriction(FGR). Methods: The rat model of FGR was established by passive smoking method. The rats offspring were divided into the FGR group and the control group, then randomly divided into the trained and untrained group, respectively. Morris water maze test was proceeded on postnatal month(PM2/4) as a behavior training method, then the learning-memory of rats was detected through dark-avoidance and step-down tests. The expressions of NR2B and GluR1 subunits in hippocampal CA1 and CA3 areas were detected by immunohistochemical method. Results: In the dark-avoidance and step-down tests, the performance record of rats with FGR was worse than that of control rats, and the behavior-trained rats was better than the untrained rats, when the FGR model and training factors were analyzed singly. The model factor and training factor had significant interaction(P < 0.05). The expressions of NR2B and GluR1 subunits in hippocampal CA1 and CA3 areas of rats with FGR reduced. In contrast, the expressions of GluR1 and NR2B subunits in CA1 area of behavior-trained rats increased, when the FGR model and training factors were analyzed singly. Conclusion: These findings suggested that the effect of behavior training on the expressions of NR2B and GluR1 subunits in CA1 area should be the mechanistic basis for the training-induced improvement in learning-memory abilities.
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