文章摘要
Guoqiang Wang,Shuyu Wang,Qun Shen,Shiwei Yin,Chunping Li,Aiping Li,Jianyong Li,Jianwei Zhou,Qizhan Liu.[J].南京医科大学学报,2009,29(2):93~99
Polymorphisms in XRCC5, XRCC6, XRCC7 genes are involved in DNA double-strand breaks(DSBs) repair associated with the risk of acute myeloid leukemia(AML) in Chinese population
投稿时间:2009-01-13  
DOI:10.7655
中文关键词: 
英文关键词: XRCC5  XRCC6  XRCC7  single nucleotide polymorphism  tandem repeat polymorphism  acute myeloid leukemia
基金项目:
作者单位
Guoqiang Wang Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
Shuyu Wang Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
Qun Shen Department of Hematology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing 210029, China 
Shiwei Yin Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
Chunping Li Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
Aiping Li Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
Jianyong Li Department of Hematology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing 210029, China 
Jianwei Zhou Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
Qizhan Liu Department of Health Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China 
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中文摘要:
      
英文摘要:
      Objective:To investigate the association between the X-ray repair cross complementing(XRCC) group 5, XRCC6 and XRCC7 polymorphisms and risk of acute myeloid leukemia(AML). Methods:This hospital-based case-control study included 120 AML patients and 210 cancer-free controls in a Chinese population. Three polymorphisms of XRCC5, XRCC6 and XRCC7 were genotyped using the polymerase chain reaction(PCR) or polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method. Results: We found that there was a significant decrease in risk of AML associated with the XRCC6 -61 CG/GG genotype(adjusted odd ratio(OR) = 0.55; 95% confident interval(CI) = 0.34-0.89) compared with the -61CC genotype. For the novel tandem repeat polymorphism (VNTR) in the XRCC5 promoter, we found when the XRCC5 six genotypes were dichotomized(i.e., 2R/2R, 2R/1R versus 2R/0R, 1R/1R, 1R/0R and 0R/0R), the latter group was associated with increased risk of AML(adjusted OR = 1.67; 95% CI = 1.00~2.79) compared to 2R/2R+2R/1R genotype. However, the XRCC7 6721G>T polymorphism had no effect on risk of AML. Conclusion:The XRCC6 -61C > G and XRCC5 2R/1R/0R polymorphisms, but not XRCC7 6721G > T polymorphism, could play an important role in the development of AML. Larger scale studies with more detailed data on environment exposure are needed to verify these findings.
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