文章摘要
Changtai Zhu,Chunlei Dong,Yinze Kong,Lingxia Liu,Qingsi Wu,Yuyou Yao.[J].南京医科大学学报,2009,29(2):143~145
Microdilution inhibition test of Chinese herbs to assess their effect against clinical strains of Ureaplasma urealyticum in vitro
投稿时间:2008-12-30  
DOI:10.7655
中文关键词: 
英文关键词: Ureaplasma urealyticum  microdilution inhibition test  Chinese herbs  minimal inhibitory concentration  antibacterial
基金项目:
作者单位
Changtai Zhu Department of Laboratory Medicine, Changzhou Cancer Hospital, Suzhou University, Changzhou 213001, China 
Chunlei Dong Department of Laboratory Medicine, Changzhou Cancer Hospital, Suzhou University, Changzhou 213001, China 
Yinze Kong Department of Science Education, Changzhou Cancer Hospital, Suzhou University, Changzhou 213001, China 
Lingxia Liu Department of Laboratory Medicine, Changzhou Cancer Hospital, Suzhou University, Changzhou 213001, China 
Qingsi Wu Department of Laboratory Medicine, Anhui Medical University, Hefei 230022, China 
Yuyou Yao Department of Laboratory Medicine, Anhui Medical University, Hefei 230022, China 
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中文摘要:
      
英文摘要:
      Objective:To explore the antibacterial effect of Chinese crude drugs against clinical strains of Ureaplasma urealyticum(UU), including eight pure herbs and three compound herbs, and determine their minimal inhibitory concentrations(MICs). Methods:Isolates were collected from clinical patients with UU infection, and cultured in UU broth. In order to test the different effects on clinical strains of UU, the assays were performed by microdilution inhibition tests, and MICs of the herbs against the clinical strains of UU were calculated. Results:The MICs of eight pure herbs against clinical strains of UU were as follows: Galla Chinensis:0.313~1.25 g/L; Fructus Forsythiae: 1.25~5.00 g/L; Cortex Phellodendri:1.25~5.00 g/L; Radix Paeoniae Rubra:1.25~2.50 g/L; Semen Plantaginis:2.50~10.00 g/L; Herba Lysimachiae: 5.00~20.00 g/L; Rhizoma Coptidis: 5.00~20.00g/L, Herba Houttuyniae: 10.00~20.00 g/L. The MICs of compound herbs were: Liuheji: 0.625~2.50 g/L; Bazhengsan: 5.00~20.00 g/L; Wulinsan:2.50~20.0 g/L.Conclusion:Galla Chinensis, Fructus Forsythiae, Cortex Phellodendrim, Radix Paeoniae Rubra, and Semen Plantaginis, exerted the stronger antibacterial effect against clinical strains of UU, whereas Herba Lysimachiae, Rhizoma Coptidis and Herba Houttuyniae, had relatively weaker activity against UU. Compound herbs, Bazhengsan and Wulinsan, and particularly Liuheji, also had antibacterial effects against UU. Further studies of the effects and mechanisms of action of Chinese crude drugs against UU infections are worthwhile.
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