文章摘要
Qing Lü,Huiyu Li,Xiaoming Lu,Guobin Wang.[J].南京医科大学学报,2009,29(3):157~162
HERG K+ channels expression in gastric cancers and analysis of its regulation in tumor cell proliferation and apoptosis
投稿时间:2009-02-26  
DOI:10.7655
中文关键词: 
英文关键词: gastric carcinoma  HERG K+ channel  herg 1 gene  proliferation  apoptosis
基金项目:
作者单位
Qing Lü Department of Gastrointestinal Surgery, Union Hospital of Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022, China 
Huiyu Li Center for Stem cell Research and Application, Institute of Hematology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 
Xiaoming Lu Department of Gastrointestinal Surgery, Union Hospital of Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022, China 
Guobin Wang Department of Gastrointestinal Surgery, Union Hospital of Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022, China 
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中文摘要:
      
英文摘要:
      Objective: To investigate the expression of herg1 gene in tumor tissues from gastric carcinomas and gastric carcinoma cell lines, and study the relationship between HERG K+ channel expressions and tumor cell proliferation and apoptosis. Methods: RT-PCR and PCR assays were used to detect the expression of herg1 gene in 64 gastric carcinomas and the gastric cancer cell line SGC-7901. Blocking the HERG K+ channels was used to evaluate their effects on tumor cell proliferation and apoptosis. Results:The statistically significant expression of herg1 gene was detected in all the gastric cancers and SGC-7901 cells, but not in normal tissues. The HERG K+ channel blocker, E-4031, increased the cell population in G0/G1(P < 0.05) and the number of apoptotic tumor cells(P < 0.05). Conclusion: HERG K+ channels were expressed in all gastric carcinomas tested and these channels appear to modulate tumor cell proliferation and apoptosis.
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