文章摘要
Takashi Shimada,Yunqing Cai,Lei Cheng,Chie Motonaga,Kazutake Fukada,Yoshihisa Kitamura,Jieshu Wu.[J].南京医科大学学报,2009,29(3):173~176
Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice
投稿时间:2009-01-14  
DOI:10.7655
中文关键词: 
英文关键词: FK-23  immunologic function  probiotics
基金项目:
作者单位
Takashi Shimada China-Japan Collaborating Centre for Probiotics Research, Nanjing Medical University, Nanjing, 210029, China 
Yunqing Cai China-Japan Collaborating Centre for Probiotics Research, Nanjing Medical University, Nanjing, 210029, China 
Lei Cheng China-Japan Collaborating Centre for Probiotics Research, Nanjing Medical University, Nanjing, 210029, China 
Chie Motonaga Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie518-1417, Japan 
Kazutake Fukada Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie518-1417, Japan 
Yoshihisa Kitamura China-Japan Collaborating Centre for Probiotics Research, Nanjing Medical University, Nanjing, 210029, China 
Jieshu Wu China-Japan Collaborating Centre for Probiotics Research, Nanjing Medical University, Nanjing, 210029, China 
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中文摘要:
      
英文摘要:
      Objective:The purpose of this study was to evaluate the effects of Enterococcus faecalis FK-23(FK-23) on the immune function in mice. Methods:Mice were treated with three doses of the FK-23(0.05, 0.1, 0.2, 0.6 g/kg body weight) for 30 days. Delayed type hypersensitivity (DTH), monocyte phagocytic function, serum hemolysis antibody and natural killer cell activity were studied. Results:The significant increases in mice treated with 0.6 g/kg bw were found in DTH, phagocytic function of monocyte, serum hemolysis antibody and natural killer cell activity. Conclusion:The results from the present study suggest that FK-23 could improve both specific and non-specific immune function.
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