文章摘要
Li Zhang,Lei Dong,Jia Liu,Xiaolan Lu,Jun Zhang.[J].南京医科大学学报,2009,29(3):183~188
Endoscopic ablation of Barrett’s esophagus using the second generation argon plasma coagulation: a prospective randomized controlled trail
投稿时间:2008-11-10  
DOI:10.7655
中文关键词: 
英文关键词: Barrett’s esophagus  argon plasma coagulation  efficacy  safety
基金项目:
作者单位
Li Zhang Department of Digestive Disease, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University
Xi’an 710004, China 
Lei Dong Department of Digestive Disease, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University
Xi’an 710004, China 
Jia Liu Department of Orthopedics, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University
Xi’an 710004, China 
Xiaolan Lu Department of Digestive Disease, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University
Xi’an 710004, China 
Jun Zhang Department of Digestive Disease, the Second Affiliated Hospital, Medical School of Xi’an Jiaotong University
Xi’an 710004, China 
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中文摘要:
      
英文摘要:
      Objective:To investigate the efficacy and safety of the second generation argon plasma coagulation(VIO APC) in the ablation of Barrett’s Esophagus. Methods:A total of 35 patients with uncomplicated Barrett’s esophagus entered into a prospective, randomized, unblinded study comparing the treatment VIO APC combined with a proton pump inhibiter with a proton pump inhibiter administered alone. VIO APC was performed at a power setting of 40W, and argon gas flow at 1.5-2.0 L/min, and“forced”mode. Ablative treatment was repeated until either no Barrett’s epithelium remained or a maximum of 5 treatment sessions occurred. Results:In the ablation group, macroscopic complete ablation was achieved in 14 of 18 patients, and complete ablation confirmed by histology in 12 of 18 patients(P < 0.01). Buried glands were observed in 2 patients who had achieved macroscopic ablation. The Barrett’s mucosa averaged a reduction of 65%(range 50-75%) in the remaining 4 patients. In the control group, only 2 patients had partial regression, median 30%(range 20-40%). In the ablation group, post-treatment 4 patients had transient retrosternal pain, and 3 patients had mild epigastric discomfort. One patient had a small hemorrhage during the procedure, which ceased after norepinephrine and thrombosin were administered through the endoscope biopsy channel. No adverse events were observed in the control group. During 11.8(4-15) months follow-up, patients who had achieved the complete ablation have no evidence of relapse of Barrett’s esophagus. Conclusion:VIO APC with a relatively low power setting can effectively ablate the Barrett’s mucosa. No severe adverse events were observed. Long-term follow-up is needed to assess cancer prevention and the durability of the neo-squamous epithelium.
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