文章摘要
Hua Huang,Juan Wu,Guangfu Jin,Hanze Zhang,Yanbing Ding,Zhaolai Hua,Yan Zhou,Yan Xue,Yan Lu,Zhibin Hu,Yaochu Xu,Hongbing Shen.[J].南京医科大学学报,2010,(2):100~106
A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population
投稿时间：2010-01-05  
DOI：10.7655
中文关键词: 
英文关键词: toll-like receptor 4, polymorphisms, susceptibility, gastric cancer
基金项目:
作者单位
Hua Huang Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Juan Wu Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Guangfu Jin Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Hanze Zhang Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Yanbing Ding Department of Gastroenterology, Yangzhou First People's Hospital, Yangzhou 225009, Jiangsu, China 
Zhaolai Hua Department of Epidemiology, Yangzhong Cancer Institute, Yangzhong 212200, Jiangsu, China 
Yan Zhou Department of Oncology, Yixing People's Hospital, Yixing 214200, Jiangsu, China 
Yan Xue Department of Gastroenterology, Yangzhou First People's Hospital, Yangzhou 225009, Jiangsu, China 
Yan Lu Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Zhibin Hu Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Yaochu Xu Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
Hongbing Shen Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu, China 
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中文摘要:
      
英文摘要:
      Objective: Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to gastric cancer in a Chinese population. Methods: Two variations in the 5'-flanking region of TLR4 (rs1927914 T > C and rs10759932 T > C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population. Results: Individuals carrying the C allele of rs10759932 had a significantly reduced risk of gastric cancer (adjusted OR = 0.81; 95%CI = 0.67-0.96), compared with the wild-type homozygote (TT), and the protective effect was not significantly different among subgroups stratified by age, sex, smoking, drinking and H.pylori infection status (P for heterogeneity > 0.05). No significant association was observed between rs1927914 and gastric cancer risk in this study population. Conclusion: The T to C allele substitution of rs10759932 may play a protective role in gastric carcinogenesis in a Chinese population. Large studies with different ethnic populations are warranted to confirm these findings.
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