文章摘要
Yuxuan Zhou,Yuan Yuan,Juan Gao,Ling Yang,Feng Zhang,Guoqing Zhu,Xingya Gao.[J].南京医科大学学报,2010,(2):107~114
An Implanted Closed-loop Chip System for Heart Rate Control: System Design and Effects in Conscious Rats
  
DOI:10.7655
中文关键词: 
英文关键词: closed-loop regulation, implanted chip system, set point, heart rate, vagus nerve stimulation, Remote-controlled animal
基金项目:
作者单位
Yuxuan Zhou Department of Biomedical Engineering, Nanjing Medical University, Nanjing, 210029, China 
Yuan Yuan Department of Biomedical Engineering, Nanjing Medical University, Nanjing, 210029, China 
Juan Gao Department of Physiology, Nanjing Medical University, Nanjing, 210029, China 
Ling Yang Department of Biomedical Engineering, Nanjing Medical University, Nanjing, 210029, China 
Feng Zhang Department of Physiology, Nanjing Medical University, Nanjing, 210029, China 
Guoqing Zhu Department of Physiology, Nanjing Medical University, Nanjing, 210029, China 
Xingya Gao Department of Physiology, Nanjing Medical University, Nanjing, 210029, China 
摘要点击次数: 3414
全文下载次数: 553
中文摘要:
      
英文摘要:
      Objective: To evaluate the efficiency of an implanted chip system for the control of heart rate (HR). Methods: The HR was recorded in six conscious Sprague-Dawley (SD) rats. An implanted chip system was designed to regulate the HR by stimulating the right cervical vagus nerve according to the feedback of real time HR. Each rat was subjected to 30-min regulation and 30-min recovery. The change of HR during the regulation period was compared with the control. The ECG was recorded during the experiment for 24 h. Results: The ECG signals were successfully recorded during the experiment. The HR was significantly decreased during the period of regulation compared with control (-79.3 ± 34.5, P < 0.01, n = 6) and then recovered to normal after regulation. Conclusion: The described implanted chip system can regulate the HR to a designated set point.
查看全文   查看/发表评论  下载PDF阅读器
关闭