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A B P=0.048
20
15.5
15 （ log2 TPM+1 ） 16.0
group 15.0
-lgP 10 Down
A2M expression
No sig
Up 14.5
5 14.0

0 0
-2 -1 0 1 2 Contorl COPD
log2 fold change
C leukocyle migration D muscle system process
granulocyte chemotaxis leukocyte migration
muscle system process cell chemotaxis
leukocyte chemotaxis muscle contraction
leukccyte chemotaxis
neutrophil chemotaxis myeloid leukocyte migration BP
myeloid leukocyte migration BP granulccyte chemotaxis
granulocyte migration granulocyte migration
cell chemotaxis neutrophil chemotaxis
neutrophil migration neutrophil migration Count
muscle contraction callagen⁃containing extracellular matrix 10
colagen⁃containing extracellular matrix endophasmic reticulum lumen 20
secretory granule lumen
endoplasmic reticulum lumen P value cytopasmic vesicle lumen 30
tertiary granule lumen vesicle lumen P value
secretory granule lumen 0.025 organelle outer membrane CC
cytoplasmic vesicle lumen outer membrane 0.125
high⁃dersity lipoprotein particle CC 0.050 contractile fiber 0.100
tertiary granule lumen
vesicle lumen 0.075 high⁃density lipoprotein particle 0.075
organelle outer membrane 0.100 0.050
outer membrane 0.125 receptor ligand activity 0.025
contractile fiber signaling receptor activator activity
cytokine activity
collagen binding glycosaminoglycan binding
cytokine receptor binding
RAGE receptor binding extracellular matnx structural constituent MF
cytokine activity collagen binding
glycosaminoqlycan binding extracellular matrix extracellular matrix binding
structural constituent RAGE receptor binding
extracellular matrix binding MF laminin binding
receptor ligand activity
signaling receptor activator activity 0.02 0.04 0.06 0.08
cytokine receptor binding GeneRatio
laminin binding
0 10 20 30
Count
E p53 signaling pathway F Cytokine⁃cytokine receptor interaction
Cytokine⁃cytokine receptor interaction Transcriptional misregulation in cancer
Mineral absorption Apoptosis
Apoptosis Lipid and atherosclerosis
TNF signaling pathway TNF signaling pathway
Tyrosine metabolism p53 signaling pathway
IL⁃17 signaling pathway IL⁃17 signaling pathway
Platinum drug resistance Viral protein interaction with cytokine and
Viral protein interaction with cytokine and cytokine receptor Count
cytokine receptor Fluid shear stress and atherosclerosis
Tryptophan metabolism Mineral absorption 4
Transcriptional misregulation in cancer Platinum drug resistance 8
Antifolate resistance P value Aldosterone synthesis and secretion 12
Malaria Protein digestion and absorption
Apoptosis⁃multiple species 0.005 Insulin resistance 16
Drug metabolism⁃cytochrome P450 0.010 Relaxin signaling pathway
Aldosterone synthesis and secretion 0.015 Drug metabolism⁃cytochrome P450 P value
Metabolism of xenobiotics by cytochrome P450 0.020 Metabolism of xenobiotics by cytochrome P450 0.025
Rheumatoid arthritis
Protein digestion and absorption AGE⁃RAGE signaling pathway in diabetic 0.020
Legionellosis 0.025 complications
Insulin resistance Amoebiasis 0.015
Fluid shear stress and atherosclerosis Tyrosine metabolism 0.010
Bladder cancer Tryptophan metabolism 0.005
Fatty acid degradation Malaria
Rheumatoid arthritis
Chemical carcinogenesis⁃DNA adducts Legionellosis
Lipid and atherosclerosis Chemical carcinogenesis⁃DNA adducts
AGE⁃RAGE signaling pathway in diabetic Antifolate resistance
complications Apoptosis⁃multiple species
Ether lipid metabolism Fatty acid degradation
Relaxin signaling pathway
Amoebiasis Ether lipid metabolism
0.02 0.04 0.06 0.08
0 5 10 15
Count GeneRatio
A：Volcano plot of differentially expressed genes in GSE38974 dataset. B：Expression levels of the A2M gene between the control and COPD group
in GSE38974 dataset. C，D：GO enrichment bar plot（C）and dotplot（D）analysis of differentially expressed genes in GSE38974 dataset. E，F：KEGG
pathway enrichment barplot（E）and dotplot（F）analysis of differentially expressed genes in GSE38974 dataset. BP：biological process；CC：cellular
component；MF：molecular function.
图1 GSE38974数据集中COPD肺组织和正常样本差异表达基因的鉴定和富集分析
Figure 1 Identification and enrichment analysis of differentially expressed genes between COPD lung tissue and normal
samples in GSE38974 dataset