This study selected 6 826 older adults suffering from chronic diseases in China Healthy Aging and Tracking（CHARLS）2020 data who were≥ 60 years old. The related data were statistically analyzed，and found that gender，age，place of residence，marital status，alcohol consumption status，degree of daily work and labor，the number of chronic diseases，sleep duration and the degree of somatic pain were influential factors in the depressive symptoms of older adults with chronic diseases. The degree of somatic pain and sleep duration had a chain-mediated effect and an independent-mediated effect on the number of multimorbidity and depressive symptoms of older adults. It is essential to emphasize the impact of multimorbidity on depressive symptoms and the management of somatic pain in older adults，early prevention and treatment of somatic pain， maintenance of a good mood，appropriate increase in the number of hours of exercise and sleep，and increase in the number of leisure and recreational activities，to reduce the depressive symptoms in older adults with multimorbidity and to improve the quality of life of older adults in health.